Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer Journal Article
| Authors: | Herr, H. W.; Bochner, B. H.; Dalbagni, G.; Donat, S. M.; Reuter, V. E.; Bajorin, D. F. |
| Article Title: | Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer |
| Abstract: | Purpose: We postulate that the number of lymph nodes examined in cystectomy specimens can have an impact on the outcome of patients with bladder cancer. Materials and Methods: We analyzed data on 322 patients with muscle invasive bladder cancer who underwent radical cystectomy and bilateral pelvic lymphadenectomy. We evaluated the associations of the number of lymph nodes identified by the pathologist in the surgical specimen with the local recurrence rate and survival outcome. Results: Patients were divided into groups by lymph node status and the distribution of the number of lymph nodes examined. In stages pN0 and pN+ cases improved survival was associated with a greater number of lymph nodes examined. We determined that at least 9 lymph nodes should be studied to define lymph node status accurately. Conclusions: These results indicate that surgical resection and pathological assessment of an adequate number of lymph nodes in cystectomy specimens increases the likelihood of proper staging and impacts patient outcome. Such information is important not only for the therapy and prognosis of individuals, but also for identifying those who may benefit from adjuvant chemotherapy. |
| Keywords: | adult; aged; survival analysis; retrospective studies; major clinical study; histopathology; cancer recurrence; advanced cancer; cancer staging; lymph node metastasis; pelvis lymph node; lymph nodes; lymphatic metastasis; neoplasm staging; lymphadenectomy; proportional hazards models; bladder cancer; urinary bladder neoplasms; cancer invasion; cystectomy; outcomes research; neoplasm invasiveness; bladder neoplasms; carcinoma, transitional cell; bladder muscle; muscle, smooth; bladder; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 167 |
| Issue: | 3 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2002-03-01 |
| Start Page: | 1295 |
| End Page: | 1298 |
| Language: | English |
| PUBMED: | 11832716 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0022-5347(05)65284-6 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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