Diagnostic X-rays and risk of epithelial ovarian carcinoma in Jews Journal Article


Authors: Harlap, S.; Olson, S. H.; Barakat, R. R.; Caputo, T. A.; Forment, S.; Jacobs, A. J.; Nakraseive, C.; Xue, X.
Article Title: Diagnostic X-rays and risk of epithelial ovarian carcinoma in Jews
Abstract: PURPOSE: To test the hypothesis that there would be ethnic differences in susceptibility to ionizing radiation from diagnostic x-rays. METHODS: In a hospital-based study we compared reports of diagnostic x-rays to the lower abdomen and pelvis in incident cases of epithelial ovarian carcinoma (N = 161), community controls (N = 156) and convenience controls (N = 87). RESULTS: Thirty-nine per cent of cases and 31% of controls recalled x-rays more than 10 years before; 27% of cases and 14% of controls reported four Jewish grandparents. Comparing the cases with community controls, the odds ratio (95% confidence interval) for Jews versus non-Jews among women reporting no x-rays was 1.02 (0.37-2.79); among women reporting x-rays the estimate for Jews was 8.91 (2.00-39.6). Consistent results were seen with inclusion of convenience controls. Jewish cases reported an excess of pelvic diagnostic x-rays from age 20 onward and an excess of barium enemas and pyelograms. CONCLUSIONS: These preliminary findings require confirmation in other studies. They suggest that the known excess risk of this carcinoma in Jews might be associated with exposure to x-rays and add to a previous observation of an altered susceptibility to ionizing radiation in Jews. If confirmed, they would suggest a need for continued vigilance to evaluate the risks and benefits of diagnostic x-rays in individuals, regardless of ethnic origin, who might carry mutations in DNA repair genes. Copyright © 2002 Elsevier Science Inc.
Keywords: adult; aged; middle aged; major clinical study; case control study; case-control studies; united states; ovarian neoplasms; dna repair; genetic predisposition to disease; odds ratio; risk factors; confidence intervals; neoplasms, radiation-induced; genetic susceptibility; carcinoma; ovary carcinoma; rna translation; new york city; ethnic difference; jews; jew; x ray; translational research; ethnic groups; barium enema; brca1/2; host factors; diagnostic radiation; humans; human; female; priority journal; article; ovary neoplasms
Journal Title: Annals of Epidemiology
Volume: 12
Issue: 6
ISSN: 1047-2797
Publisher: Elsevier Science, Inc.  
Date Published: 2002-08-01
Start Page: 426
End Page: 434
Language: English
DOI: 10.1016/s1047-2797(01)00301-5
PUBMED: 12160602
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 14 November 2014 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Richard R Barakat
    609 Barakat
  2. Sara H Olson
    213 Olson