An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer Journal Article
| Authors: | Akhurst, T.; Downey, R. J.; Ginsberg, M. S.; Gonen, M.; Bains, M.; Korst, R.; Ginsberg, R. J.; Rusch, V. W.; Larson, S. M. |
| Article Title: | An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer |
| Abstract: | Background. The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over computed tomography alone in the staging of untreated nonsmall cell lung cancer (NSCLC). Aside from one 9-patient study, there are no data comparing FDG-PET imaging with surgical staging of NSCLC after induction therapy. Methods. We reviewed our institutional experience with FDG-PET imaging followed by surgical staging of nonsmall cell lung cancer after induction therapy. A nuclear physician blinded to surgical findings reviewed the FDG-PET scans and assigned a clinical TNM stage. A thoracic surgeon assigned a pathologic TNM stage. Then the clinical TNM stage and the pathologic TNM stage were compared. Results. Fifty-six patients (30 males and 26 females; median, age 60) with nonsmall cell lung cancer underwent chemotherapy (40 patients), chemoradiation (11 patients), or radiation alone (5 patients) followed by PET and operations. PET had a positive predictive value of 98% for detecting residual viable disease in the primary tumor. PET over-staged nodal status in 33% of patients, under staged nodal status in 15%, and was correct in 52%. PET correctly classified all patients with M1 disease. Conclusions. Positron emission tomography after induction therapy accurately detects residual viable primary tumor, but not the involvement of mediastinal lymph nodes. © 2002 by The Society of Thoracic Surgeons. |
| Keywords: | adult; cancer survival; retrospective studies; major clinical study; cancer staging; positron emission tomography; antineoplastic agent; neoplasm staging; diagnostic accuracy; radiopharmaceuticals; computer assisted tomography; image analysis; image interpretation, computer-assisted; carcinoma, non-small-cell lung; lung neoplasms; lung cancer; diagnostic imaging; retrospective study; neoplasm, residual; fluorodeoxyglucose f18; fluorodeoxyglucose; tomography, emission-computed; mediastinum lymph node; humans; human; male; female; priority journal; article |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 73 |
| Issue: | 1 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2002-01-01 |
| Start Page: | 259 |
| End Page: | 266 |
| Language: | English |
| DOI: | 10.1016/s0003-4975(01)03257-x |
| PUBMED: | 11834020 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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