An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer Journal Article


Authors: Akhurst, T.; Downey, R. J.; Ginsberg, M. S.; Gonen, M.; Bains, M.; Korst, R.; Ginsberg, R. J.; Rusch, V. W.; Larson, S. M.
Article Title: An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer
Abstract: Background. The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over computed tomography alone in the staging of untreated nonsmall cell lung cancer (NSCLC). Aside from one 9-patient study, there are no data comparing FDG-PET imaging with surgical staging of NSCLC after induction therapy. Methods. We reviewed our institutional experience with FDG-PET imaging followed by surgical staging of nonsmall cell lung cancer after induction therapy. A nuclear physician blinded to surgical findings reviewed the FDG-PET scans and assigned a clinical TNM stage. A thoracic surgeon assigned a pathologic TNM stage. Then the clinical TNM stage and the pathologic TNM stage were compared. Results. Fifty-six patients (30 males and 26 females; median, age 60) with nonsmall cell lung cancer underwent chemotherapy (40 patients), chemoradiation (11 patients), or radiation alone (5 patients) followed by PET and operations. PET had a positive predictive value of 98% for detecting residual viable disease in the primary tumor. PET over-staged nodal status in 33% of patients, under staged nodal status in 15%, and was correct in 52%. PET correctly classified all patients with M1 disease. Conclusions. Positron emission tomography after induction therapy accurately detects residual viable primary tumor, but not the involvement of mediastinal lymph nodes. © 2002 by The Society of Thoracic Surgeons.
Keywords: adult; cancer survival; retrospective studies; major clinical study; cancer staging; positron emission tomography; antineoplastic agent; neoplasm staging; diagnostic accuracy; radiopharmaceuticals; computer assisted tomography; image analysis; image interpretation, computer-assisted; carcinoma, non-small-cell lung; lung neoplasms; lung cancer; diagnostic imaging; retrospective study; neoplasm, residual; fluorodeoxyglucose f18; fluorodeoxyglucose; tomography, emission-computed; mediastinum lymph node; humans; human; male; female; priority journal; article
Journal Title: Annals of Thoracic Surgery
Volume: 73
Issue: 1
ISSN: 0003-4975
Publisher: Elsevier Science, Inc.  
Date Published: 2002-01-01
Start Page: 259
End Page: 266
Language: English
DOI: 10.1016/s0003-4975(01)03257-x
PUBMED: 11834020
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 14 November 2014 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Robert J Korst
    26 Korst
  2. Valerie W Rusch
    657 Rusch
  3. Michelle S Ginsberg
    159 Ginsberg
  4. Mithat Gonen
    716 Gonen
  5. Timothy J Akhurst
    134 Akhurst
  6. Robert J Downey
    203 Downey
  7. Steven M Larson
    778 Larson
  8. Manjit S Bains
    229 Bains