Response of Diamond-Blackfan anemia to metoclopramide: Evidence for a role for prolactin in erythropoiesis Journal Article
| Authors: | Abkowitz, J. L.; Schaison, G.; Boulad, F.; Brown, D. L.; Buchanan, G. R.; Johnson, C. A.; Murray, J. C.; Sabo, K. M. |
| Article Title: | Response of Diamond-Blackfan anemia to metoclopramide: Evidence for a role for prolactin in erythropoiesis |
| Abstract: | A 47-year-old woman with severe macrocytic anemia markedly improved during the second and third trimesters of 3 pregnancies and when breast-feeding her 2 children. Because the serum prolactin level is elevated at these times, we later treated her with metoclopramide (10 mg orally 3 times daily), a medication known to induce prolactin release. Her serum prolactin levels increased from 7 to 133 ng/mL (normal < 20 ng/mL) and hematocrit from 17% to 22% to 35%. With continued therapy (now 10 mg orally daily), her hematocrit has ranged from 30% to 40% for 6 years, although the macrocytosis persists (mean corpuscular volume, 100-112 fL). On the basis of this observation, a pilot study was undertaken of metoclopramide therapy in patients with Diamond-Blackfan anemia who were refractory to low doses of corticosteroids. Fifteen patients were enrolled and 9 completed the planned 16 weeks of therapy. Three individuals responded, suggesting that this therapeutic approach may benefit others. As with the index case, the anemia did not improve until 12 to 15 weeks of therapy had been completed. © 2002 by The American Society of Hematology. |
| Keywords: | adolescent; adult; child; clinical article; controlled study; treatment outcome; middle aged; human cell; androgen; prednisone; clinical trial; disease course; fatigue; drug efficacy; evidence based medicine; treatment indication; controlled clinical trial; erythropoiesis; drug effect; disease severity; drug mechanism; pilot projects; multicenter study; drug response; remission; pregnancy; mean corpuscular volume; methylprednisolone; corticosteroid; metoclopramide; cyclosporin; drug induced disease; hematocrit; prolactin; prolactin blood level; refractory anemia; interleukin 3; breast feeding; macrocytic anemia; megalocytosis; humans; human; male; female; priority journal; article; second trimester pregnancy; blackfan diamond anemia; prolactin release; anemia, diamond-blackfan; pregnancy complications, hematologic |
| Journal Title: | Blood |
| Volume: | 100 |
| Issue: | 8 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2002-10-15 |
| Start Page: | 2687 |
| End Page: | 2691 |
| Language: | English |
| DOI: | 10.1182/blood.V100.8.2687 |
| PUBMED: | 12351372 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
