SOX17 links gut endoderm morphogenesis and germ layer segregation Journal Article

   


Authors: Viotti, M.; Nowotschin, S.; Hadjantonakis, A. K.
Article Title: SOX17 links gut endoderm morphogenesis and germ layer segregation
Abstract: Gastrulation leads to three germ layers-ectoderm, mesoderm and endoderm-that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic visceral endoderm (VE). Here we image the trajectory of prospective DE cells before intercalating into the VE epithelium. We show that the transcription factor SOX17, which is activated in prospective DE cells before intercalation, is necessary for gut endoderm morphogenesis and the assembly of the basement membrane that separates gut endoderm from mesoderm. Our results mechanistically link gut endoderm morphogenesis and germ layer segregation, two central and conserved features of gastrulation.
Keywords: gene; endoderm; mouse embryo; expression; specification; primitive streak; eomesodermin; establishment; chick-embryo; definitive; embryonic-stem-cells
Journal Title: Nature Cell Biology
Volume: 16
Issue: 12
ISSN: 1465-7392
Publisher: Nature Publishing Group  
Date Published: 2014-12-01
Start Page: 1146
End Page: 1156
Language: English
ACCESSION: WOS:000345777300006
DOI: 10.1038/ncb3070
PROVIDER: wos
PMCID: PMC4250291
PUBMED: 25419850
Notes: Article -- Source: Wos
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MSK Authors
  1. Sonja Nowotschin
    37 Nowotschin
  2. Anna-Katerina Hadjantonakis
    191 Hadjantonakis
  3. Manuel Viotti
    8 Viotti
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