Clinical characteristics and outcomes for patients with thymic carcinoma evaluation of Masaoka staging Journal Article
| Authors: | Litvak, A. M.; Woo, K.; Hayes, S.; Huang, J.; Rimner, A.; Sima, C. S.; Moreira, A. L.; Tsukazan, M.; Riely, G. J. |
| Article Title: | Clinical characteristics and outcomes for patients with thymic carcinoma evaluation of Masaoka staging |
| Abstract: | Background: Thymic carcinomas are rare cancers with limited data regarding outcomes, particularly for those patients with advanced disease. Methods: We identified patients with thymic carcinomas diagnosed between 1993 and 2012. Patient characteristics, recurrence-free survival (RFS), and overall survival (OS) were analyzed. Results: One hundred twenty-one patients with thymic carcinomas were identified. Higher Masaoka stage was associated with worse OS and RFS (5-year OS of 100%, 81%, 51%, 24%, and 17% for stage I, II, III, IVa, and IVb respectively, p < 0.001 and 5-year RFS of 80%, 28%, and 7% for stage I/II, III, and IV respectively, p < 0.001). Patients with stage IVb lymph node (LN) only disease had a better 5-year OS as compared with patients with distant metastasis (24% versus 7%, p = 0.025). Of the 61 patients with stage IVb disease, 22 of 29 patients (76%) with LN-only disease underwent curative intent resection versus 3 of 32 patients (9%) with distant metastasis. Twenty-two patients with LN involvement were treated with multimodality therapy. Three (14%) remain free of disease with long-term follow-up (range, 3.4+ years- to 6.8+ years). Conclusions: We describe the clinical features of a large series of patients with thymic carcinoma in North America. The Masaoka staging system effectively prognosticated OS and RFS. Patients with stage IVb LN-only disease had significantly better OS as compared with patients with distant metastasis with a subset of patients sustaining long-term RFS with multimodality therapy. If validated, these data would support a revised staging system with subclassification of stage IVb disease into two groups. |
| Keywords: | relapse; experience; resection; thymoma; thymic carcinoma; squamous-cell carcinoma; system; retrospective analysis; multicenter; single institution; predict prognosis; masaoka staging |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 9 |
| Issue: | 12 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-12-01 |
| Start Page: | 1810 |
| End Page: | 1815 |
| Language: | English |
| ACCESSION: | WOS:000345559900012 |
| DOI: | 10.1097/jto.0000000000000363 |
| PROVIDER: | wos |
| PUBMED: | 25393794 |
| PMCID: | PMC4663074 |
| Notes: | Article -- Source: Wos |
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