Diagnosis and management of DNA mismatch repair-deficient colorectal cancer Journal Article
| Author: | Stadler, Z. K. |
| Article Title: | Diagnosis and management of DNA mismatch repair-deficient colorectal cancer |
| Abstract: | Colorectal tumors exhibiting defective DNA mismatch repair (MMR-D)/microsatellite instability (MSI-H) form a distinct subgroup of CRCs associated with important clinical and pathologic features. The identification of MMR-D/MSI-H may impact CRC prognosis, prediction of response to chemotherapeutic agents, and may necessitate the need for genetic assessment for Lynch syndrome. Oncologists remain at the forefront of diagnosing, treating, and managing patients with MMR-D/MSI-H CRC and ensuring that the clinical care of these patients reflect our evolving understanding of this unique CRC subtype. |
| Keywords: | microsatellite instability; mismatch repair deficiency; colorectal cancer prognosis |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 29 |
| Issue: | 1 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-02-01 |
| Start Page: | 29 |
| End Page: | 41 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2014.09.008 |
| PROVIDER: | scopus |
| PUBMED: | 25475571 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
