GNAQ and GNA11 mutations in uveal melanoma Journal Article
| Authors: | Shoushtari, A. N.; Carvajal, R. D. |
| Article Title: | GNAQ and GNA11 mutations in uveal melanoma |
| Abstract: | G-protein-coupled receptors signal through heterotrimeric G proteins, Ga and G-βγ, to manage numerous aspects of physiologic homeostasis. Many neoplastic processes harbor alterations in G-protein-coupled receptors and/or G-a proteins, best exemplified by recurrent activating mutations in GNAQ or GNA11 in uveal melanomas. This review will discuss the multiple activated signaling targets downstream of mutant GNAQ and GNA11 in uveal melanoma, including MEK, PI3-kinase/Akt, protein kinase C, and YAP. This knowledge has led to the rapid expansion of clinical trials that are specific to patients with uveal melanoma and promises future breakthroughs in therapies. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein kinase b; gene mutation; review; cancer combination chemotherapy; drug efficacy; monotherapy; nonhuman; drug targeting; enzyme inhibition; mitogen activated protein kinase inhibitor; phosphatidylinositol 3 kinase; carcinogenesis; protein kinase c; mutation rate; uvea melanoma; tumor gene; alpha chain; transcription factor yap1; g protein coupled receptor; protein kinase c inhibitor; futurology; g protein; map kinase; molecularly targeted therapy; yap; gna11; gnaq; uveal melanoma; gna11 gene; gnaq gene; selumetinib; pi3-kinase; trametinib; human; binimetinib; alpelisib; sotrastaurin; uprosertib |
| Journal Title: | Melanoma Research |
| Volume: | 24 |
| Issue: | 6 |
| ISSN: | 0960-8931 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2014-12-01 |
| Start Page: | 525 |
| End Page: | 534 |
| Language: | English |
| DOI: | 10.1097/cmr.0000000000000121 |
| PROVIDER: | scopus |
| PUBMED: | 25304237 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
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