Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast Journal Article

   


Authors: Piscuoglio, S.; Ng, C. K. Y.; Martelotto, L. G.; Eberle, C. A.; Cowell, C. F.; Natrajan, R.; Bidard, F. C.; De Mattos-Arruda, L.; Wilkerson, P. M.; Mariani, O.; Vincent-Salomon, A.; Weigelt, B.; Reis-Filho, J. S.
Article Title: Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast
Abstract: Papillary carcinoma (PC) is a rare type of breast cancer, which comprises three histologic subtypes: encapsulated PC (EPC), solid PC (SPC) and invasive PC (IPC). Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profiling, and RNA-sequencing revealed that PCs are luminal breast cancers that display transcriptomic profiles distinct from those of grade- and estrogen receptor (ER)-matched invasive ductal carcinomas of no special type (IDC-NSTs), and that the papillary histologic pattern is unlikely to be underpinned by a highly recurrent expressed fusion gene or a highly recurrent expressed mutation. Despite displaying similar patterns of gene copy number alterations, significant differences in the transcriptomic profiles of EPCs, SPCs and IPCs were found, and may account for their different histologic features.
Keywords: controlled study; gene mutation; human cell; mutation; histopathology; gene expression profiling; transcriptomics; rna; dna; breast carcinoma; fusion gene; genomics; gene dosage; papillary carcinoma; estrogen receptor; rna sequence; microarrays; human; article; rna-sequencing; single nucleotide polymorphism arrays; breast encapsulated papillary carcinoma; breast invasive papillary carcinoma; breast solid papillary carcinoma
Journal Title: Molecular Oncology
Volume: 8
Issue: 8
ISSN: 1878-0261
Publisher: FEBS Press  
Date Published: 2014-12-01
Start Page: 1588
End Page: 1602
Language: English
DOI: 10.1016/j.molonc.2014.06.011
PROVIDER: scopus
PUBMED: 25041824
PMCID: PMC5037246
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84911967623&partnerID=40&md5=96efc06ff39eb1085b8d9c8aa242d3b4
Notes: Export Date: 2 January 2015 -- Source: Scopus
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MSK Authors
  1. Carey Eberle
    17 Eberle
  2. Britta Weigelt
    633 Weigelt
  3. Jorge Sergio Reis-Filho
    639 Reis-Filho
  4. Francois-Clement Bidard
    17 Bidard
  5. Kiu Yan Charlotte Ng
    155 Ng
  6. Salvatore Piscuoglio
    130 Piscuoglio
  7. Luciano Gaston Martelotto
    69 Martelotto
  8. Catherine Frances Cowell
    10 Cowell
  9. Leticia De Mattos Arruda
    15 De Mattos Arruda
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