Primary angiosarcoma of bone a retrospective analysis of 60 patients from 2 institutions Journal Article
| Authors: | Palmerini, E.; Maki, R. G.; Staals, E. L.; Alberghini, M.; Antonescu, C. R.; Ferrari, C.; Ruggieri, P.; Mavrogenis, A.; Bertoni, F.; Cesari, M.; Paioli, A.; Marchesi, E.; Picci, P.; Ferrari, S. |
| Article Title: | Primary angiosarcoma of bone a retrospective analysis of 60 patients from 2 institutions |
| Abstract: | Background: Angiosarcoma of bone is a rare high-grade malignant vascular tumor. The literature regarding treatment and outcome of patients with this tumor is limited. We performed a 2 institutional retrospective study to analyze treatment and survival of patients with angiosarcoma of bone. Patients and Methods: We reviewed patients with the histologic diagnosis of primary angiosarcoma of bone treated from 1980 to 2009. Demographic details, histology, treatment, and survival were reviewed. Results: A total of 38 men and 22 women (median age, 54 y) were recruited. Most lesions occurred in the femur and the pelvis. Metastatic disease at presentation was diagnosed in 24 patients (40%). Forty-three patients underwent surgery, with 30 of them achieving surgical complete remission (SCR). Radiotherapy was applied to 17 patients, and chemotherapy to 13/35 and 15/22 patients with localized and metastatic disease, respectively. The 5-year overall survival (OS) was 20%: 33% for patients with localized disease and 0% for metastatic patients. Higher 5-year OS was reported for patients who achieved SCR (46%) than for those who did not (0%). In nonmetastatic patients, a trend toward improved survival was observed after SCR and adjuvant chemotherapy based on cisplatin, doxorubicin, and ifosfamide. Fifteen patients received chemotherapy for metastases. Two RECIST partial responses of 13 evaluable patients were documented (paclitaxel [n = 1] and doxorubicin [n = 1]). Stable disease was observed in 2 patients. Conclusions: Complete surgical resection is essential for outcome. Survival of patients with metastatic or unresectable disease is very poor. Activity of taxanes and anthracycline was observed in the metastatic setting and merits further evaluation. |
| Keywords: | osteosarcoma; adult; cancer survival; treatment outcome; cancer surgery; survival rate; major clinical study; overall survival; sorafenib; bevacizumab; cisplatin; doxorubicin; cancer combination chemotherapy; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; chemotherapy; metastasis; angiosarcoma; retrospective study; ifosfamide; survival time; cancer regression; surgery; anthracycline; orthopedic surgery; human; male; female; article; angiosarcoma of bone; bone angiosarcoma |
| Journal Title: | American Journal of Clinical Oncology |
| Volume: | 37 |
| Issue: | 6 |
| ISSN: | 0277-3732 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2014-12-01 |
| Start Page: | 528 |
| End Page: | 534 |
| Language: | English |
| DOI: | 10.1097/COC.0b013e31827defa1 |
| PROVIDER: | scopus |
| PMCID: | PMC3681918 |
| PUBMED: | 23466575 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
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