Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases Journal Article
| Authors: | Macauley, M. S.; Arlian, B. M.; Rillahan, C. D.; Pang, P. C.; Bortell, N.; Marcondes, M. C. G.; Haslam, S. M.; Dell, A.; Paulson, J. C. |
| Article Title: | Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases |
| Abstract: | Conclusion: Sialoside expression can be modulated in vivo with a sialyltransferase inhibitor. Significance: Pharmacological blockade of sialoside expression will be an important tool for future exploration of sialic acid in health and disease. Background: In vivo pharmacological inhibition of sialyltransferases has, to date, not been possible. Results: 3F-NeuAc acts as a global sialyltransferase inhibitor in mice and causes kidney and liver dysfunction. |
| Keywords: | mus; sialyltransferase; sialyltransferases; mammals; biochemistry; sialic acids; sialylation; pharmacological inhibition; global inhibitors; pharmacological blockade; sialoside |
| Journal Title: | Journal of Biological Chemistry |
| Volume: | 289 |
| Issue: | 51 |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Date Published: | 2014-12-19 |
| Start Page: | 35149 |
| End Page: | 35158 |
| Language: | English |
| DOI: | 10.1074/jbc.M114.606517 |
| PROVIDER: | scopus |
| PMCID: | PMC4271204 |
| PUBMED: | 25368325 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
