Adenocarcinoma of the pancreas Journal Article
| Authors: | Hruban, R. H.; Klimstra, D. S. |
| Article Title: | Adenocarcinoma of the pancreas |
| Abstract: | Infiltrating ductal adenocarcinoma of the pancreas is a real enigma. On one hand, it is one of the most deadly of all of the solid malignancies. On the other hand, the neoplastic glands can be remarkably well-differentiated, and it can be difficult to distinguish between a reactive non-neoplastic gland and a gland of invasive adenocarcinoma. In this review, we will present diagnostic criteria that one can "hang your hat on" when establishing the diagnosis of infiltrating ductal adenocarcinoma of the pancreas. We will also review clinically important features of the disease, and, with the impending incorporation of molecular genetics into everyday practice, we will emphasize clinical applications of cancer genetics. |
| Keywords: | clinical feature; histopathology; microscopy; pancreas cancer; molecular genetics; cancer diagnosis; adenocarcinoma; pancreas; cancer therapy; cancer genetics; cancer infiltration; chronic pancreatitis; pancreas adenocarcinoma; pancreatic cancer; tumor classification; antibody labeling; smad4 protein; germline mutation; tumor invasion; pancreas adenoma; smad4 gene; human; article |
| Journal Title: | Seminars in Diagnostic Pathology |
| Volume: | 31 |
| Issue: | 6 |
| ISSN: | 0740-2570 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-11-01 |
| Start Page: | 443 |
| End Page: | 451 |
| Language: | English |
| DOI: | 10.1053/j.semdp.2014.08.004 |
| PROVIDER: | scopus |
| PUBMED: | 25441308 |
| PMCID: | PMC4313868 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
