Cisplatin-induced antitumor immunomodulation: A review of preclinical and clinical evidence Journal Article
| Authors: | De Biasi, A. R.; Villena-Vargas, J.; Adusumilli, P. S. |
| Article Title: | Cisplatin-induced antitumor immunomodulation: A review of preclinical and clinical evidence |
| Abstract: | Contrary to the long held belief that chemotherapy is immunosuppressive, emerging evidence indicates that the anticancer activity of cisplatin is not limited to its ability to inhibit mitosis, but that cisplatin also has important immunomodulatory effects. We therefore methodically examined the relevant preclinical literature and identified four main mechanisms of cisplatin-induced antitumor immunomodulation: (i) MHC class I expression upregulation; (ii) recruitment and proliferation of effector cells; (iii) upregulation of the lytic activity of cytotoxic effectors; and (iv) downregulation of the immunosuppressive microenvironment. Cisplatin-based combination chemotherapy's antitumor immunomodulatory effects are also beginning to be harnessed in the clinic; we therefore additionally reviewed the applicable clinical literature and discussed how monitoring various components of the immune system (and their responses to cisplatin) can add new levels of sophistication to disease monitoring and prognostication. In summation, this growing body of literature on cisplatin-induced antitumor immunomodulation ultimately highlights the therapeutic potential of synergistic strategies that combine traditional chemotherapy with immunotherapy. |
| Keywords: | review; cisplatin; fluorouracil; nonhuman; paclitaxel; cell proliferation; ovary cancer; gene expression; antineoplastic activity; protein p53; ifosfamide; adjuvant chemotherapy; cytolysis; effector cell; immunomodulation; down regulation; upregulation; navelbine; suppressor cell; esophageal squamous cell carcinoma; small cell lung cancer; non small cell lung cancer; tumor microenvironment; human |
| Journal Title: | Clinical Cancer Research |
| Volume: | 20 |
| Issue: | 21 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2014-11-01 |
| Start Page: | 5384 |
| End Page: | 5391 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-14-1298 |
| PROVIDER: | scopus |
| PMCID: | PMC4216745 |
| PUBMED: | 25204552 |
| DOI/URL: | |
| Notes: | Export Date: 1 December 2014 -- Source: Scopus |
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