Synapse - Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands Journal Article

Authors:	Weinreb, I.; Piscuoglio, S.; Martelotto, L. G.; Waggott, D.; Ng, C. K. Y.; Perez-Ordonez, B.; Harding, N. J.; Alfaro, J.; Chu, K. C.; Viale, A.; Fusco, N.; Da Cruz Paula, A.; Marchio, C.; Sakr, R. A.; Lim, R.; Thompson, L. D. R.; Chiosea, S. I.; Seethala, R. R.; Skalova, A.; Stelow, E. B.; Fonseca, I.; Assaad, A.; How, C.; Wang, J.; De Borja, R.; Chan-Seng-Yue, M.; Howlett, C. J.; Nichols, A. C.; Wen, Y. H.; Katabi, N.; Buchner, N.; Mullen, L.; Kislinger, T.; Wouters, B. G.; Liu, F. F.; Norton, L.; McPherson, J. D.; Rubin, B. P.; Clarke, B. A.; Weigelt, B.; Boutros, P. C.; Reis-Filho, J. S.
Article Title:	Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
Abstract:	Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
Journal Title:	Nature Genetics
Volume:	46
Issue:	11
ISSN:	1061-4036
Publisher:	Nature Publishing Group
Date Published:	2014-11-01
Start Page:	1166
End Page:	1169
Language:	English
DOI:	10.1038/ng.3096
PROVIDER:	scopus
PUBMED:	25240283
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84908867220&partnerID=40&md5=09faaf4266b837ba7fd6f187384c83bc
Notes:	Export Date: 1 December 2014 -- Source: Scopus