Repeated courses of Rituximab in chronic ITP: Three different regimens Journal Article
| Authors: | Hasan, A.; Michel, M.; Patel, V.; Stasi, R.; Cunningham Rundles, S.; Leonard, J. P.; Bussel, J. |
| Article Title: | Repeated courses of Rituximab in chronic ITP: Three different regimens |
| Abstract: | This study investigated responses to retreatment with rituximab in chronic immune thrombocytopenic purpura (ITP) patients. Treatment with rituximab in chronic ITP patients induces long-lasting responses in ∼30% of patients but even these patients may relapse. Twenty patients who had achieved a response to rituximab and relapsed were retreated with rituximab (375 mg/m<sup>2</sup>x 4); this data was analyzed retrospectively. Subsequently, 16 patients were prospectively randomized to receive rituximab with cyclophosphamide, vincristine and prednisone (R-CVP) or double dose rituximab (DDR). Retreatment with standard dose rituximab demonstrated responses similar to initial rituximab treatment in 15 of 20 patients. Neither of the two more intensive regimens (R-CVP, DDR) induced responses in any patient who had previously failed to respond to rituximab nor induced substantially longer-lasting responses among previous responders. No additional toxicity was noted with the DDR regimen, whereas R-CVP was not well tolerated. These results suggest that retreatment with standard dose rituximab induces similar responses in 75% of previously responding patients and is well tolerated. Neither combining rituximab with CVP nor doubling the dose of rituximab increased the response rate. © 2009 Wiley-Liss, Inc. |
| Keywords: | clinical article; controlled study; prednisone; clinical trial; drug tolerability; cancer patient; rituximab; controlled clinical trial; multiple cycle treatment; randomized controlled trial; cyclophosphamide; vincristine; medical record review; retrospective study; chronic disease; drug response; cancer relapse; idiopathic thrombocytopenic purpura; allergic reaction; retreatment |
| Journal Title: | American Journal of Hematology |
| Volume: | 84 |
| Issue: | 10 |
| ISSN: | 0361-8609 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 661 |
| End Page: | 665 |
| Language: | English |
| DOI: | 10.1002/ajh.21512 |
| PROVIDER: | scopus |
| PMCID: | PMC2783818 |
| PUBMED: | 19731307 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: AJHED" - "Source: Scopus" |
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