The role of stereotactic body radiotherapy and stereotactic radiosurgery in the re-irradiation of metastatic spinal tumors Journal Article
| Authors: | Jain, A. K.; Yamada, Y. |
| Article Title: | The role of stereotactic body radiotherapy and stereotactic radiosurgery in the re-irradiation of metastatic spinal tumors |
| Abstract: | Stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) are advanced radiotherapy delivery techniques that allow for the delivery of high-dose per fraction radiation. Advances in imaging technology and intensity modulation have allowed SRS and SBRT to be used for the treatment of tumors in close proximity to the spinal cord and cauda equina, in particular spinal metastases. While the initial treatment of spinal metastases is often conventional palliative radiotherapy, treatment failure is not uncommon, and conventional re-irradiation may not be feasible due to spinal cord tolerance. SBRT and SRS have emerged as important techniques for the treatment of spinal metastases in the proximity of previously irradiated spinal cord. Here we review the current data on the use of SBRT and SRS spinal re-irradiation, and future directions for these important treatment modalities. |
| Keywords: | treatment outcome; fatigue; review; cancer risk; dose response; nonhuman; cancer patient; cancer radiotherapy; radiation dose; clinical practice; treatment indication; quality of life; pain; esophagitis; radiation injury; risk assessment; symptom; dosimetry; spinal cord tumor; nausea and vomiting; stereotactic body radiotherapy; stereotactic radiosurgery; cancer control; stereotactic body radiation therapy; neurologic disease; retreatment; spinal cord metastasis; phase 2 clinical trial (topic); spinal metastases; phase 1 clinical trial (topic); re-irradiation; compression fracture; human; spinal cord tolerance; biological effective dose; radiation myelopathy |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 14 |
| Issue: | 10 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2014-10-01 |
| Start Page: | 1141 |
| End Page: | 1152 |
| Language: | English |
| DOI: | 10.1586/14737140.2014.940326 |
| PROVIDER: | scopus |
| PUBMED: | 25066490 |
| DOI/URL: | |
| Notes: | Export Date: 3 November 2014 -- Source: Scopus |
