Strategies for targeting the androgen receptor axis in prostate cancer Journal Article


Author: Carver, B. S.
Article Title: Strategies for targeting the androgen receptor axis in prostate cancer
Abstract: Androgen receptor (AR) signaling plays a critical role in prostate cancer cell proliferation, survival, and differentiation. Therapeutic strategies targeting the androgen receptor have been developed for the treatment of metastatic hormone-naïve prostate cancer; however, despite effective targeting recent studies have demonstrated that during progression to a castrate-resistant phenotype there is restoration of AR target gene expression. On the basis of this observation, second-generation therapeutics have been developed to target AR in the castrate-resistant setting resulting in a survival benefit. In this review we will discuss the mechanisms promoting AR signaling and the development of second-generation therapeutics targeting AR in castrate-resistant prostate cancer.
Keywords: signal transduction; cancer survival; review; cancer patient; phenotype; gene expression; prostate cancer; androgen receptor; antiandrogen; castration resistant prostate cancer; phase 3 clinical trial (topic); androgen synthesis; human
Journal Title: Drug Discovery Today
Volume: 19
Issue: 9
ISSN: 1359-6446
Publisher: Elsevier Inc.  
Date Published: 2014-09-01
Start Page: 1493
End Page: 1497
Language: English
DOI: 10.1016/j.drudis.2014.07.008
PROVIDER: scopus
PUBMED: 25107669
DOI/URL:
Notes: Export Date: 3 November 2014 -- Source: Scopus
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  1. Brett Stewart Carver
    143 Carver