Development of cell cycle inhibitors in the treatment of gastrointestinal cancers Journal Article

  


Author: Schwartz, G. K.
Article Title: Development of cell cycle inhibitors in the treatment of gastrointestinal cancers
Abstract: Therapeutic targets have been identified as progress has been made in the understanding of the cell cycle. Cell cycle checkpoints guard genetic fidelity by arresting cells at specific stages of the cell cycle. Drugs have been developed that induce cell cycle arrest, and the application of these drugs to colon cancer cell lines is presented.
Keywords: clinical article; clinical trial; neutropenia; cisplatin; fluorouracil; diarrhea; side effect; conference paper; drug targeting; antineoplastic agent; genetic analysis; colorectal cancer; cell cycle; irinotecan; digestive system cancer; cancer inhibition; colon cancer; cancer cell; flavopiridol; phase 1 clinical trial; cpt-11; ucn-01; dose time effect relation; mitosis inhibition; 7 hydroxystaurosporine; human; cell cycle inhibitors; cell cycle inhibition
Journal Title: Journal of Clinical Ligand Assay
Volume: 26
Issue: 1
ISSN: 1081-1672
Publisher: Clinical Ligand Assay Society  
Date Published: 2003-01-01
Start Page: 43
End Page: 44
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0142072657&partnerID=40&md5=a5e0d6d45793d49149feb85d74a68ec0
Notes: Export Date: 25 September 2014 -- Source: Scopus