Immunology of paraneoplastic syndromes: Overview Conference Paper
| Author: | Posner, J. B. |
| Title: | Immunology of paraneoplastic syndromes: Overview |
| Conference Title: | 10th International Conference on Myasthenia Gravis and Related Disorders |
| Abstract: | Cancers that cause disturbances of organs or tissues remote from the site of the tumor or its metastases are called paraneoplastic syndromes. The nervous system can be affected at virtually any site, including the neuromuscular junction (e.g., Lambert-Eaton myasthenic syndrome, myasthenia gravis). Paraneoplastic syndromes affecting the central nervous system are characterized by (1) high titers of antibodies that react with both the cancer and the affected portion of the nervous system, (2) specifically reacting T cells in the blood and cerebrospinal fluid, and (3) autopsy evidence of neuronal destruction, inflammatory infiltrates, and antibody penetration. Clinically, paraneoplastic syndromes affecting the central nervous system are usually subacute in onset, rapid in evolution, and cause severe damage, but generally stabilize after several months with or without treatment. Immune suppression does not appear to be particularly effective in treating these disorders. Treatment of the underlying cancer sometimes ameliorates symptoms. |
| Keywords: | clinical feature; conference paper; cancer incidence; neoplasms; t lymphocyte; animals; disease association; cancer immunotherapy; incidence; immunoglobulin; plasmapheresis; disease severity; cerebrospinal fluid; cancer cytodiagnosis; brain metastasis; autoimmunity; inflammatory infiltrate; autopsy; eaton lambert syndrome; myasthenia gravis; paraneoplastic syndrome; thymoma; onset age; thymus neoplasms; autoantibodies; thymus cancer; antibody titer; immunopathogenesis; nerve cell necrosis; nervous system diseases; neuromuscular synapse; antigen antibody reaction; paraneoplastic syndromes; paraneoplastic; cancer; humans; human; allotype suppression |
| Journal Title | Annals of the New York Academy of Sciences |
| Volume: | 998 |
| Conference Dates: | 2002 May 29-Jun 1 |
| Conference Location: | Key Biscayne, FL |
| ISBN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2003-09-01 |
| Start Page: | 178 |
| End Page: | 186 |
| Language: | English |
| DOI: | 10.1196/annals.1254.018 |
| PUBMED: | 14592873 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter in "Myasthenia Gravis and Related Disorders: Biomchemical Basis for Disease of the Neuromuscular Junction" (ISBN: 9781573313964) -- Export Date: 25 September 2014 -- Source: Scopus |
