Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: Meeting summary Journal Article
| Authors: | Gorlick, R.; Anderson, P.; Andrulis, I.; Arndt, C.; Beardsley, G. P.; Bernstein, M.; Bridge, J.; Cheung, N. K.; Dome, J. S.; Ebb, D.; Gardner, T.; Gebhardt, M.; Grier, H.; Hansen, M.; Healey, J.; Helman, L.; Hock, J.; Houghton, J.; Houghton, P.; Huvos, A.; Khanna, C.; Kieran, M.; Kleinerman, E.; Ladanyi, M.; Lau, C.; Malkin, D.; Marina, N.; Meltzer, P.; Meyers, P.; Schofield, D.; Schwartz, C.; Smith, M. A.; Toretsky, J.; Tsokos, M.; Wexler, L.; Wigginton, J.; Withrow, S.; Schoenfeldt, M.; Anderson, B. |
| Article Title: | Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: Meeting summary |
| Abstract: | Childhood osteogenic sarcoma (OS) is a rare bone cancer occurring primarily in adolescents. The North American pediatric cooperative groups have performed a series of clinical treatment trials in this disease over the past several decades, and biology studies of tumor tissue have been an important study component. A meeting was held in Bethesda, Maryland on November 29-30, 2001, sponsored by the NIH Office of Rare Diseases, the Children's Oncology Group, and the National Cancer Institute-Cancer Therapy Evaluation Program with the general objectives: (a) to review the current state of knowledge regarding OS biology; (b) to identify, prioritize, and support the development of biology studies of potential clinical relevance in OS; and (c) to discuss the available tissue resources and the appropriate methods for analysis of OS samples for the conduct of biology studies. This report summarizes the information presented and discussed by the meeting participants. |
| Keywords: | osteosarcoma; child; protein expression; bone neoplasms; pathogenesis; united states; conference paper; cell death; gene expression; angiogenesis; neovascularization, pathologic; growth hormone; cancer inhibition; cytokine; somatomedin c; folic acid antagonist; angiogenesis inhibitors; north america; bone cancer; glycoprotein p; virus pathogenesis; humans; human; priority journal |
| Journal Title: | Clinical Cancer Research |
| Volume: | 9 |
| Issue: | 15 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2003-11-15 |
| Start Page: | 5442 |
| End Page: | 5453 |
| Language: | English |
| PUBMED: | 14654523 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
