Medical history, lifestyle, family history, and occupational risk factors for lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia: The InterLymph non-Hodgkin lymphoma subtypes project Journal Article


Authors: Vajdic, C. M.; Landgren, O.; McMaster, M. L.; Slager, S. L.; Brooks-Wilson, A.; Smith, A.; Staines, A.; Dogan, A.; Ansell, S. M.; Sampson, J. N.; Morton, L. M.; Linet, M. S.
Article Title: Medical history, lifestyle, family history, and occupational risk factors for lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia: The InterLymph non-Hodgkin lymphoma subtypes project
Abstract: Background: Lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM), a rare non-Hodgkin lymphoma subtype, shows strong familial aggregation and a positive association with chronic immune stimulation, but evidence regarding other risk factors is very limited. Methods: The International Lymphoma Epidemiology Consortium (InterLymph) pooled data from 11 predominantly population-based case-control studies from North America, Europe, and Australia to examine medical history, lifestyle, family history, and occupational risk factors for LPL/WM. Age-, sex-, race/ethnicity-, and study-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression for a total of 374 LPL/WM cases and 23 096 controls. Results: In multivariate analysis including all putative risk factors, LPL/WM risk was associated with history of Sjögren's syndrome (OR = 14.0, 95% CI = 3.60 to 54.6), systemic lupus erythematosus (OR = 8.23, 95% CI = 2.69 to 25.2), hay fever (OR = 0.73, 95% CI = 0.54 to 0.99), positive hepatitis C serology (OR = 2.51, 95% CI = 1.03 to 6.17), hematologic malignancy in a first-degree relative (OR = 1.64, 95% CI = 1.02 to 2.64), adult weight (OR = 0.61, 95% CI = 0.44 to 0.85 for highest vs. lowest quartile), duration of cigarette smoking (OR = 1.46, 95% CI = 1.04 to 2.05 for ≥ 40 years vs. nonsmokers), and occupation as a medical doctor (OR = 5.54, 95% CI = 2.19 to 14.0). There was no association with other medical conditions, lifestyle factors, or occupations. Conclusions: This pooled analysis confirmed associations with immune conditions and family history of hematologic malignancy, and identified new associations with hay fever, weight, smoking, and occupation, and no association with other lifestyle factors. These findings offer clues to LPL/WM biology and prevention.
Journal Title: Journal of the National Cancer Institute - Monographs
Issue: 48
ISSN: 1052-6773
Publisher: Oxford University Press  
Date Published: 2014-08-01
Start Page: 87
End Page: 97
Language: English
DOI: 10.1093/jncimonographs/lgu002
PROVIDER: scopus
PMCID: PMC4155457
PUBMED: 25174029
DOI/URL:
Notes: Export Date: 1 October 2014 -- Source: Scopus
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MSK Authors
  1. Ahmet Dogan
    162 Dogan