Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer Journal Article
| Authors: | Siegel, P. M.; Massagué, J. |
| Article Title: | Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer |
| Abstract: | The cytostatic and apoptotic functions of transforming growth factor-β (TGF-β) help restrain the growth of mammalian tissues; loss of these effects leads to hyperproliferative disorders and is common in cancer. However, tumour cells that are relieved from TGF-β growth constraints might then overproduce this cytokine to create a local immunosuppressive environment that fosters tumour growth and exacerbates the invasive and metastatic behaviour of the tumour cells themselves. For these reasons, there is a growing interest in understanding and therapeutically targeting TGF-β-mediated processes in cancer progression. |
| Keywords: | signal transduction; review; cancer growth; nonhuman; protein function; neoplasms; cell proliferation; apoptosis; transforming growth factor beta; protein targeting; cytokine; disease progression; tumor cell; neoplasm metastasis; neoplasm invasiveness; tumor growth; immune deficiency; homeostasis; cell invasion; tissue growth; cytostasis; immunosuppression; humans; priority journal |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 3 |
| Issue: | 11 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-11-01 |
| Start Page: | 807 |
| End Page: | 820 |
| Language: | English |
| PUBMED: | 14557817 |
| PROVIDER: | scopus |
| DOI: | 10.1038/nrc1208 |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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