Targeting tumours with genetically enhanced T lymphocytes Journal Article
| Authors: | Sadelain, M.; Rivière, I.; Brentjens, R. |
| Article Title: | Targeting tumours with genetically enhanced T lymphocytes |
| Abstract: | The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy. |
| Keywords: | genetics; review; neoplasm; neoplasms; lymphocyte proliferation; t lymphocyte; tumor associated leukocyte; lymphocytes, tumor-infiltrating; t-lymphocytes; cancer immunotherapy; transforming growth factor beta; antineoplastic activity; tumor antigen; risk assessment; monoclonal antibody; t lymphocyte receptor; regulatory t lymphocyte; antigen presentation; immunology; antibodies, monoclonal; dna modification; immunotherapy; antigens, neoplasm; antigen specificity; receptors, antigen, t-cell; t-lymphocytes, regulatory; antigen recognition; autoimmunity; immunological adjuvant; adjuvants, immunologic; t lymphocyte activation; lymphocyte antigen receptor; lymphokine activated killer cell; humans; human; priority journal; killer cells, lymphokine-activated |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 3 |
| Issue: | 1 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-01-01 |
| Start Page: | 35 |
| End Page: | 45 |
| Language: | English |
| DOI: | 10.1038/nrc971 |
| PUBMED: | 12509765 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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