Permanent prostate brachytherapy in men with clinically localised prostate cancer Journal Article
| Author: | Potters, L. |
| Article Title: | Permanent prostate brachytherapy in men with clinically localised prostate cancer |
| Abstract: | Permanent prostate brachytherapy techniques are associated with excellent biochemical control for patients with localised prostate cancer. Ten-year data show that permanent prostate brachytherapy is compatible with external beam irradiation or radical prostatectomy. However, treatment protocols and techniques for prostate brachytherapy vary between centres and there is little conformity of treatment protocols. The selection of patients for monotherapy or combined external beam irradiation and brachytherapy is controversial. The role of neoadjuvant androgen deprivation also remains unanswered in patients with localised prostate cancer. In addition, post-implant dosimetry may in fact be more significant for predicting outcome than the addition of adjuvant therapies, and should be a requirement when performing prostate brachytherapy. Data now seem to support specific computed tomography (CT)-based criteria to evaluate implant quality and delivered dose to the prostate. Unfortunately, prostate oedema and poor imaging techniques are limiting factors for evaluating implant dosimetry. Treatment planning techniques that use new treatment planning computers may assist in improving the implant procedure and dosimetry and are now available. © 2003 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. |
| Keywords: | treatment outcome; androgen; constipation; review; diarrhea; monotherapy; multimodality cancer therapy; patient selection; treatment planning; cancer adjuvant therapy; cancer radiotherapy; chemotherapy, adjuvant; edema; computer assisted tomography; steroid; clinical protocol; antineoplastic activity; diagnostic imaging; prediction; hematuria; prostate cancer; prostatic neoplasms; cancer center; iodine 125; dosimetry; prostatectomy; nomograms; androgen antagonists; urinary frequency; brachytherapy; radiometry; antiandrogen; gonadorelin agonist; gonadorelin derivative; drug half life; cancer control; erectile dysfunction; urine retention; outcomes; impotence; palladium 103; dysuria; gastrointestinal diseases; alpha adrenergic receptor blocking agent; sexual dysfunction, physiological; intestine function disorder; tamsulosin; ejaculation disorder; male sexual dysfunction; rectum fistula; proctitis; rectum disease; urinary tract disease; urination disorders; doxazosin; terazosin; defecation disorder; phenazopyridine; humans; human; male; priority journal; drug implantation; hemospermia; rectum ulcer |
| Journal Title: | Clinical Oncology |
| Volume: | 15 |
| Issue: | 6 |
| ISSN: | 0936-6555 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-09-01 |
| Start Page: | 301 |
| End Page: | 315 |
| Language: | English |
| DOI: | 10.1016/s0936-6555(03)00152-3 |
| PUBMED: | 14524482 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
