The cellular response to DNA double-strand breaks: Defining the sensors and mediators Journal Article
| Authors: | Petrini, J. H. J.; Stracker, T. H. |
| Article Title: | The cellular response to DNA double-strand breaks: Defining the sensors and mediators |
| Abstract: | The induction of DNA double-strand breaks (DSBs) culminates in the activation of cell cycle checkpoint responses and DNA repair machinery. The mechanism of DSB detection remains unclear although many candidate sensor proteins have been identified through cytologic, biochemical and genetic studies. In light of recent advances in our understanding of the cellular response to DSBs, we have proposed criteria for defining sensor proteins. We discuss the possible role of the Mre11 complex as a primary damage sensor and the complex relationship between DNA damage sensors, transducers and mediators. |
| Keywords: | dna-binding proteins; review; nonhuman; mammalia; dna damage; cell cycle; complex formation; dna repair; nuclear proteins; double stranded dna; dna structure; models, molecular; trans-activators; cell activity; isoprotein; molecular conformation; mammal cell; transducer; sensor; mediator; humans; priority journal |
| Journal Title: | Trends in Cell Biology |
| Volume: | 13 |
| Issue: | 9 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-09-01 |
| Start Page: | 458 |
| End Page: | 462 |
| Language: | English |
| DOI: | 10.1016/s0962-8924(03)00170-3 |
| PUBMED: | 12946624 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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