Multimodality management of locally advanced rectal cancer Journal Article
| Authors: | Moore, H. G.; Guillem, J. G. |
| Article Title: | Multimodality management of locally advanced rectal cancer |
| Abstract: | Despite the routine use of adjuvant chemoradiation for curatively resected stage II and HI rectal cancer a significant percentage of patients ultimately fail locally and/or distally; this underscores the need for continued improvement in the efficacy of combined-modality therapy and quality of rectal cancer resection. The recognition of the significance of lateral or circumferential margins of resection has paralleled the widespread use of total mesorectal excision. In addition to facilitating negative margins of resection and local control, sharp mesorectal techniques also facilitate identification and preservation of pelvic autonomic nerves thereby greatly reducing the incidence of urinary and sexual dysfunction following radical resection. Lastly, restorative options can result in excellent bowel function in carefully selected patients undergoing a "very low" anterior resection. Efforts are currently directed at identifying the subset of locally advanced rectal cancer patients who may be adequately treated with a resection alone thereby avoiding the added morbidity of adjuvant radiation and chemotherapy. |
| Keywords: | survival rate; mortality; review; multimodality cancer therapy; adjuvant therapy; combined modality therapy; radiotherapy, adjuvant; methodology; neoplasm recurrence, local; pathology; tumor recurrence; abdominal surgery; rectal neoplasms; rectum tumor; digestive system surgical procedures; rectum; humans; human |
| Journal Title: | American Surgeon |
| Volume: | 69 |
| Issue: | 7 |
| ISSN: | 0003-1348 |
| Publisher: | Southeastern Surgical Congress |
| Date Published: | 2003-01-01 |
| Start Page: | 612 |
| End Page: | 619 |
| Language: | English |
| PUBMED: | 12889627 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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