Immunity against soft-tissue sarcomas Journal Article
| Author: | Maki, R. G. |
| Article Title: | Immunity against soft-tissue sarcomas |
| Abstract: | Recent advances in basic medical sciences have led to a deeper understanding of the molecular characteristics of soft-tissue sarcomas. Likowise, novel tehnologies have led to a better appreciation of the relationship between an antigenic stimulus and the subsequent immune response against the antigen. In the past few years, the intersection of the understanding of the immune system and the knowledge of sarcoma biology has become apparent. As seen with other forms of cancer, there is a detectable autologous immune response against sarcomas. It is the hope of many investigators that the hints of a tumor-specific immune response will be enough to generate a signal that can be amplified and directed against the host saroma. The data regarding the initial evidence of immune responses against sarcomas are reviewed in the context of current or potential clinical studies. Copyright © 2003 by Current Science Inc. |
| Keywords: | signal transduction; treatment outcome; survival rate; unclassified drug; clinical trial; fatigue; mortality; review; nonhuman; methodology; sensitivity and specificity; evidence based medicine; cancer immunotherapy; controlled clinical trial; drug eruption; anemia; dendritic cell; randomized controlled trial; epidermal growth factor receptor 2; granulocyte macrophage colony stimulating factor; drug synthesis; telomerase; tumor antigen; physiology; fever; sarcoma; immunology; cellular immunity; immune response; immunotherapy; antigens, neoplasm; cancer vaccine; cancer vaccines; antigen specificity; randomized controlled trials; medical technology; soft tissue sarcoma; nausea and vomiting; tumor immunity; immunostimulation; heat shock protein 70; molecular biology; soft tissue neoplasms; soft tissue tumor; drug delivery system; recombinant interleukin 2; angiogenic factor; chaperone; immunity, cellular; glycolipid; heat shock protein; nose congestion; humans; prognosis; human; male; female; heat shock protein 96 |
| Journal Title: | Current Oncology Reports |
| Volume: | 5 |
| Issue: | 4 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2003-08-01 |
| Start Page: | 282 |
| End Page: | 287 |
| Language: | English |
| PUBMED: | 12781069 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s11912-003-0067-x |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
