Update on the therapeutic approaches to brain tumors Journal Article
| Authors: | Lallana, E. C.; Abrey, L. E. |
| Article Title: | Update on the therapeutic approaches to brain tumors |
| Abstract: | Neuro-oncology is a rapidly growing field of study. The understanding of brain tumors has expanded in pace with advances in the field of molecular biology and genetics. Diagnoses are more accurate, biopsy and surgical intervention safer, radiotherapy more focused and chemotherapy safer and better tolerated. Novel strategies based on the understanding of brain tumor biology are emerging as targeted approaches to therapy. Despite all this, only a minority of patients with certain subsets of brain tumors have experienced prolonged survival. This review focuses on the standard and emerging therapies for the two most common categories of brain tumors: gliomas and meningiomas. Primary CNS lymphoma, while a relatively rare tumor, is also included as a topic of discussion as the achievements in its treatment represent the principal strides in the evolution of neuro-oncology. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; school child; cancer surgery; genetics; hydroxyurea; prednisone; clinical trial; review; doxorubicin; fluorouracil; dose response; drug efficacy; drug safety; antineoplastic agents; cancer radiotherapy; combined modality therapy; chemotherapy; cytarabine; methotrexate; temozolomide; neurotoxicity; nuclear magnetic resonance imaging; brain tumor; glioma; brain neoplasms; cancer diagnosis; cancer grading; diagnostic accuracy; animals; tumor localization; alpha2b interferon; carboplatin; unindexed drug; computer assisted tomography; infection; tumor volume; etoposide; radiotherapy; cyclophosphamide; dexamethasone; vincristine; tumor biopsy; carmustine; lomustine; procarbazine; wound healing; cytokine; antibodies, monoclonal; nuclear magnetic resonance spectroscopy; tamoxifen; surgery; oligodendroglioma; safety; platinum derivative; meningioma; mifepristone; molecular biology; corticosteroid; angiogenesis inhibitors; astrocytoma; drug tolerance; antibody; polymer; drug delivery system; transferrin; chimeric protein; brain lymphoma; intracranial hypertension; diaziquone; microsphere; lonafarnib; pcnsl; nimustine; neutron capture therapy; humans; human; biologic agent; boron neutron capture therapy; biodegradable implant |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 3 |
| Issue: | 5 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2003-10-01 |
| Start Page: | 655 |
| End Page: | 670 |
| Language: | English |
| PUBMED: | 14599089 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
