Sphingolipids as therapeutics Journal Article
| Authors: | Kester, M.; Kolesnick, R. |
| Article Title: | Sphingolipids as therapeutics |
| Abstract: | The sphingolipid field has made significant strides over the past 10 years: from identifying metabolites of the sphingomyelin pathway as second messengers to discerning the molecular biology and biophysics of these lipid-derived second messengers. Building upon this vast basic science literature, scientists from multiple disciplines have begun to translate manipulations of endogenous sphingolipid metabolites and targets into therapeutic initiatives. Multiple publications have reviewed the biochemistry [Biochemistry 40 (16) (2001) 4893 [1]; Environ. Health Perspect. 109 (Suppl. 2) (2001) 283 [2]], biophysics [J. Cell Physiol. 184 (3) (2000) 285 [3]; Trends Cell Biol. 10 (10) (2000) 408 [4]], molecular biology [Biochim. Biophys. Acta 1426 (2) (1999) 347 [5]], and physiology [J. Biol. Chem. 277 (29) (2002) 25851 [6]; J. Biol. Chem. 277 (29) (2002) 25847 [7]] of sphingolipid metabolites. The present review serves to document the emerging concept of sphingolipid metabolites as therapeutics with clear clinical potential. © 2003 Elsevier Science Ltd. All rights reserved. |
| Keywords: | signal transduction; cancer chemotherapy; unclassified drug; clinical trial; review; doxorubicin; nonhuman; drug targeting; paclitaxel; cancer radiotherapy; chemical analysis; animals; mice; apoptosis; antifungal agent; cancer cell culture; drug effect; angiogenesis; cancer resistance; lymphocytopenia; molecular mechanics; molecular cloning; enzyme regulation; drug mechanism; cancer cell; stenosis; tamoxifen; radiosensitivity; chinese medicine; vinca alkaloid; taxane derivative; disease models, animal; safingol; sphingolipids; sphingosine; anthracycline; autoimmune disease; multiple sclerosis; fertility; brain ischemia; ceramide glucosyltransferase; oligonucleotide; lipid metabolism; mycosis; metabolite; phosphotransferase inhibitor; retinoid; drug delivery system; antiestrogen; complementary dna; bioavailability; therapeutics; ceramide; ceramides; cell membrane permeability; fenretinide; reperfusion injury; sphingosine 1 phosphate; sphingosine kinase; cardiovascular; sphingolipid; sphingosine derivative; cancer; humans; human; priority journal; fingolimod; 2 decanoylamino 3 morpholino 1 phenyl 1 propanol; ceramidase inhibitor; hydrolase inhibitor; inositolphosphorylceramide inhibitor; sphingosine kinase inhibitor; trimethylsphingosine; ethnopharmacology |
| Journal Title: | Pharmacological Research |
| Volume: | 47 |
| Issue: | 5 |
| ISSN: | 1043-6618 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-05-01 |
| Start Page: | 365 |
| End Page: | 371 |
| Language: | English |
| DOI: | 10.1016/s1043-6618(03)00048-3 |
| PUBMED: | 12676510 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
