Monitoring PML-RARα in acute promyelocytic leukemia Journal Article


Author: Jurcic, J. G.
Article Title: Monitoring PML-RARα in acute promyelocytic leukemia
Abstract: Acute promyelocytic leukemia (APL) is characterized by a translocation between the promyelocytic leukemia gene (PML) on chromosome 15 and the retinoic add receptor-α (RARα) gene on chromosome 17. Reverse-transcription polymerase chain reaction (RT-PCR) amplification of PML-RARα messenger RNA can establish the dagriosis of APL, predict response to all-trans retinoic acid and arsenic trioxide, detect minimal residual disease, and predict relapse. Quantitative "real-time" RT-PCR techniques may improve residual disease assessment by facilitating more rapid and standardized results. APL provides a useful model in which therapy is targeted to an underlying genetic aberration and treatment is adapted based on monitoring of residual disease. Copyright © 2003 by Current Science Inc.
Keywords: cancer chemotherapy; oncoprotein; genetics; histone deacetylase inhibitor; review; cancer recurrence; salvage therapy; treatment planning; drug targeting; cytarabine; molecular genetics; diagnostic accuracy; medical decision making; monitoring; metabolism; reverse transcription polymerase chain reaction; gene amplification; neoplasm proteins; recurrence; patient monitoring; abelson kinase; cancer model; prediction; monoclonal antibody; standardization; arsenic trioxide; leukemia, promyelocytic, acute; messenger rna; minimal residual disease; reverse transcriptase polymerase chain reaction; quantitative analysis; tumor protein; drug response; mitoxantrone; promyelocytic leukemia; oncogene proteins, fusion; remission; remission induction; recurrent disease; allogeneic hematopoietic stem cell transplantation; glyceraldehyde 3 phosphate dehydrogenase; idarubicin; diagnostic test; genetic disorder; genetic screening; retinoic acid; autologous hematopoietic stem cell transplantation; histone deacetylase; acute disease; cd33 antigen; gemtuzumab ozogamicin; autologous bone marrow transplantation; promyelocytic leukemia protein; retinoic acid receptor alpha; 4 phenylbutyric acid; monitoring, physiologic; chromosome translocation 17; humans; prognosis; human; porphobilinogen deaminase; promyelocytic leukemia retinoic acid receptor alpha fusion oncoprotein; promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; chromosome translocation 15
Journal Title: Current Oncology Reports
Volume: 5
Issue: 5
ISSN: 1523-3790
Publisher: Springer  
Date Published: 2003-09-01
Start Page: 391
End Page: 398
Language: English
PROVIDER: scopus
PUBMED: 12895391
DOI: 10.1007/s11912-003-0025-7
DOI/URL:
Notes: Export Date: 25 September 2014 -- Source: Scopus
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  1. Joseph G Jurcic
    134 Jurcic