Eph signaling: A structural view Journal Article

Authors: Himanen, J. P.; Nikolov, D. B.
Article Title: Eph signaling: A structural view
Abstract: Eph receptors, the largest subfamily of receptor tyrosine kinases, and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape and mobility. Both Ephs and ephrins are membrane-bound and their interactions at sites of cell-cell contact initiate unique bidirectional signaling cascades, with information transduced in both the receptor-expressing and the ligand-expressing cells. Recent structural and biophysical studies summarized in this review reveal unique molecular features not previously observed in any other receptor-ligand families and explain many of the biochemical and signaling properties of Ephs and ephrins. Of particular importance is the insight into how approximation of ligand-expressing and receptor-expressing cells could lead to the formation and activation of highly ordered signaling centers at cell-cell interfaces.
Keywords: signal transduction; protein expression; review; protein conformation; animals; cells, cultured; protein tyrosine kinase; tyrosine kinase receptor; ligand; ligands; binding protein; receptor protein-tyrosine kinases; cell shape; protein family; cell adhesion; cell communication; cell motility; receptors, eph family; ephrin; plant; ephrins; ephrin receptor; human; priority journal; nodulin
Journal Title: Trends in Neurosciences
Volume: 26
Issue: 1
ISSN: 0166-2236
Publisher: Elsevier Science, Inc.  
Date Published: 2003-01-01
Start Page: 46
End Page: 51
Language: English
DOI: 10.1016/s0166-2236(02)00005-x
PUBMED: 12495863
PROVIDER: scopus
Notes: Export Date: 25 September 2014 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Dimitar B Nikolov
    70 Nikolov
  2. Juha P Himanen
    42 Himanen
Related MSK Work