Eph signaling: A structural view Journal Article
| Authors: | Himanen, J. P.; Nikolov, D. B. |
| Article Title: | Eph signaling: A structural view |
| Abstract: | Eph receptors, the largest subfamily of receptor tyrosine kinases, and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape and mobility. Both Ephs and ephrins are membrane-bound and their interactions at sites of cell-cell contact initiate unique bidirectional signaling cascades, with information transduced in both the receptor-expressing and the ligand-expressing cells. Recent structural and biophysical studies summarized in this review reveal unique molecular features not previously observed in any other receptor-ligand families and explain many of the biochemical and signaling properties of Ephs and ephrins. Of particular importance is the insight into how approximation of ligand-expressing and receptor-expressing cells could lead to the formation and activation of highly ordered signaling centers at cell-cell interfaces. |
| Keywords: | signal transduction; protein expression; review; protein conformation; animals; cells, cultured; protein tyrosine kinase; tyrosine kinase receptor; ligand; ligands; binding protein; receptor protein-tyrosine kinases; cell shape; protein family; cell adhesion; cell communication; cell motility; receptors, eph family; ephrin; plant; ephrins; ephrin receptor; human; priority journal; nodulin |
| Journal Title: | Trends in Neurosciences |
| Volume: | 26 |
| Issue: | 1 |
| ISSN: | 0166-2236 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-01-01 |
| Start Page: | 46 |
| End Page: | 51 |
| Language: | English |
| DOI: | 10.1016/s0166-2236(02)00005-x |
| PUBMED: | 12495863 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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