Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis Journal Article
| Authors: | Grünert, S.; Jechlinger, M.; Beug, H. |
| Article Title: | Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis |
| Abstract: | In contrast to the aberrant control of proliferation, apoptosis, angiogenesis and lifespan, the cellular mechanisms that cause local invasion and metastasis of tumour cells are still poorly understood. New experimental approaches have identified different types of epithelial-plasticity changes in tumour cells towards fibroblastoid phenotypes as crucial events that occur during metastasis, and many molecules and signalling pathways cooperate to trigger these processes. |
| Keywords: | signal transduction; mitogen activated protein kinase; controlled study; review; nonhuman; cell proliferation; animal cell; mouse; phenotype; animals; cells, cultured; stat1 protein; metastasis; apoptosis; gene expression profiling; confocal microscopy; mitogen activated protein kinase inhibitor; transforming growth factor beta; platelet derived growth factor receptor; angiogenesis; phosphatidylinositol 3 kinase; uvomorulin; cell type; animalia; cell transformation, neoplastic; cancer invasion; gamma interferon; cell culture; tumor cell; neoplasm metastasis; transforming growth factor beta receptor; cell culture techniques; epithelium cell; epithelial cells; protein kinase c; ras protein; receptor protein-tyrosine kinases; ras proteins; nick end labeling; beta catenin; 2 morpholino 8 phenylchromone; vimentin; phosphatidylinositol 3 kinase inhibitor; 2 (2 amino 3 methoxyphenyl)chromone; collagen gel; humans; priority journal; stat2 protein |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 4 |
| Issue: | 8 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-08-01 |
| Start Page: | 657 |
| End Page: | 665 |
| Language: | English |
| DOI: | 10.1038/nrm1175 |
| PUBMED: | 12923528 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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