The development of differentiation agents for the treatment of prostate cancer Journal Article
| Authors: | Galsky, M.; Kelly, W. K. |
| Article Title: | The development of differentiation agents for the treatment of prostate cancer |
| Abstract: | Given their novel mechanisms of action and relatively favorable toxicity profiles, differentiation agents have been the focus of much investigation in the field of oncology. Among the most well studied of these agents in prostate cancer have been the retinoids, vitamin D, peroxisome-proliferator-activated receptor gamma (PPARγ) ligands, and, most recently, the histone deacetylase (HDAC) inhibitors. While the clinical activity of these agents has been limited, several obstacles to the development of these novel drugs have become apparent. A lack of validated measures of outcome and uncertainty regarding the appropriate disease states in which to test these agents have led to difficulty in trial design. Furthermore, a better understanding of the biologic targets and genes manipulated by these therapies is required such that more potent and selective drugs may be developed. By overcoming these obstacles, the full potential of this therapeutic class may be realized. © 2003 Elsevier Inc. All rights reserved. |
| Keywords: | treatment outcome; histone deacetylase inhibitor; clinical trial; review; alpha interferon; paclitaxel; antineoplastic agent; prostate specific antigen; protein bcl 2; unindexed drug; apoptosis; risk factors; dexamethasone; hypercalcemia; kidney failure; cell differentiation; calcitriol; protein p53; transcription factors; prostate cancer; prostatic neoplasms; confusion; gene expression regulation, neoplastic; prostate specific membrane antigen; transcription regulation; prostatectomy; disease progression; intracellular signaling peptides and proteins; vitamin d; dna, neoplasm; vorinostat; genomics; androgen receptor; cyproterone acetate; castration; cycline; somnolence; dna responsive element; rosiglitazone; histone deacetylases; retinoic acid; xeroderma pigmentosum; retinoid; azacitidine; zoledronic acid; arylbutyric acid derivative; glucocorticoid receptor; receptors, cytoplasmic and nuclear; fenretinide; retinoids; conjunctivitis; cheilitis; pioglitazone; trans-activation (genetics); retinoid x receptor; troglitazone; peroxisome proliferator activated receptor agonist; humans; human; male; priority journal; doxercalciferol; liarozole |
| Journal Title: | Seminars in Oncology |
| Volume: | 30 |
| Issue: | 5 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-10-01 |
| Start Page: | 689 |
| End Page: | 697 |
| Language: | English |
| DOI: | 10.1016/s0093-7754(03)00355-5 |
| PUBMED: | 14571416 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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