Use of nomograms for predicting survival in patients with castrate prostate cancer Journal Article
| Authors: | Galsky, M.; Kelly, W. K. |
| Article Title: | Use of nomograms for predicting survival in patients with castrate prostate cancer |
| Abstract: | Given the heterogeneity of prognoses in patients with castrate metastatic prostate cancer, the ability to accurately predict survival is vital for optimal patient counseling, selection of treatments, clinical trial design, and interpretation of clinical data. Over the past 20 years, several prognostic models have been developed in an attempt to refine the clinician's predictive ability. Early models were based on patients with more advanced disease. They included variables that are no longer regularly encountered today and involved cumbersome calculations that were not practical for everyday use in the clinic. Recently, 2 point-based nomograms have been developed based on pretreatment variables measured on a routine basis. These models provide a user-friendly format in which to make sophisticated predictions of survival. These models have improved our ability to predict the outcomes of patients with castrate metastatic disease. However, further work to identify novel prognostic markers to improve the accuracy of these predictions is needed. © 2003 Elsevier Inc. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; clinical trial; disease course; mortality; review; antineoplastic agent; adenocarcinoma; prostate specific antigen; metastasis; proportional hazards models; neoplasm proteins; algorithms; prediction; risk; prostate cancer; prostate-specific antigen; prostatic neoplasms; alkaline phosphatase; blood; karnofsky performance status; proportional hazards model; algorithm; disease progression; prostate tumor; tumor protein; androgen antagonists; forecasting; outcomes research; lactate dehydrogenase; antiandrogen; castration; orchiectomy; antineoplastic agents, hormonal; parameter; l-lactate dehydrogenase; nomogram; antineoplastic hormone agonists and antagonists; clinical trials; case management; humans; prognosis; human; male; priority journal |
| Journal Title: | Urology |
| Volume: | 62 |
| Issue: | Suppl. 1 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-12-29 |
| Start Page: | 119 |
| End Page: | 127 |
| Language: | English |
| DOI: | 10.1016/j.urology.2003.09.003 |
| PUBMED: | 14747049 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
