Clonal immunoglobulin DNA in the plasma of patients with AIDS lymphoma Journal Article
| Authors: | Wagner-Johnston, N. D.; Gellert, L.; Gocke, C. D.; Lemas, V. M.; Lee, J.; Martínez-Maza, O.; Ambinder, R. F. |
| Article Title: | Clonal immunoglobulin DNA in the plasma of patients with AIDS lymphoma |
| Abstract: | Immunoglobulin (Ig) gene rearrangements are used to define clonality of suspected B-lineage malignancy in tissue samples. To determine whether such rearrangements could be identified in plasma, we screened plasma from 14 consecutive patients with AIDS-related lymphoma with multiplex Ig primers. Clonally rearranged Ig DNA was detected in plasma from 7 of 14 patients. Patients in whom clonal Ig DNA remained detectable after combination chemotherapy died with lymphoma. Tumor was available from 1 patient, and the IgH amplification products from plasma and tumor were sequenced and confirmed to be identical. Ig DNA rearrangements in plasma may be useful as a lymphoma-specific tumor marker, and failure to clear clonal Ig DNA may identify patients at high risk for failure of standard therapy. © 2011 by The American Society of Hematology. |
| Keywords: | clinical article; controlled study; gene sequence; cancer combination chemotherapy; antineoplastic agent; cancer mortality; b cell lymphoma; immunoglobulin heavy chain; gene rearrangement; acquired immune deficiency syndrome; large cell lymphoma; kaposi sarcoma; immunoglobulin kappa chain; antibody blood level; primary effusion lymphoma |
| Journal Title: | Blood |
| Volume: | 117 |
| Issue: | 18 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2011-05-05 |
| Start Page: | 4860 |
| End Page: | 4862 |
| Language: | English |
| DOI: | 10.1182/blood-2010-12-324657 |
| PROVIDER: | scopus |
| PMCID: | PMC3100695 |
| PUBMED: | 21389324 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: BLOOA" - "Source: Scopus" |
