A review of second-line chemotherapy and prognostic models for disseminated germ cell tumors Journal Article
| Authors: | Voss, M. H.; Feldman, D. R.; Bosl, G. J.; Motzer, R. J. |
| Article Title: | A review of second-line chemotherapy and prognostic models for disseminated germ cell tumors |
| Abstract: | Despite an excellent prognosis even for patients with disseminated disease, about 20% to 30% of men with advanced germ cell tumors are refractory to first-line chemotherapy or experience disease recurrence after an initial remission with such treatment. Many of these are cured with conventional dose cisplatin/ifosfamide-based regimen or high-dose chemotherapy with stem cell rescue. Controversy exists regarding the optimal choice between these 2 second-line approaches, and available data for each is reviewed here. Clinical factors can help prognosticate patients, and recently an international effort developed a prognostic model for the second-line setting that can be universally applied in future studies. © 2011 Elsevier Inc. |
| Keywords: | cancer chemotherapy; overall survival; review; cancer recurrence; salvage therapy; cisplatin; disseminated cancer; patient selection; paclitaxel; chemotherapy; cancer staging; protein blood level; metastasis; progression free survival; multiple cycle treatment; nephrotoxicity; bone marrow suppression; etoposide; ifosfamide; vinblastine; drug dose escalation; cancer regression; bleomycin; cancer relapse; mesna; testis cancer; germ cell tumor; seminoma; alpha fetoprotein; chorionic gonadotropin; hormone blood level; phase 2 clinical trial (topic); phase 1 clinical trial (topic); germ cell neoplasm |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 25 |
| Issue: | 3 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-06-01 |
| Start Page: | 557 |
| End Page: | 576 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2011.03.007 |
| PROVIDER: | scopus |
| PMCID: | PMC3230321 |
| PUBMED: | 21570609 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: HCNAE" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work