Imaging cell death in vivo Journal Article
| Authors: | Blankenberg, F.; Mari, C.; Strauss, H. W. |
| Article Title: | Imaging cell death in vivo |
| Abstract: | A technique to image programmed cell death would be useful both in clinical care and in drug development. Ihe most widely studied agent for the in vivo study of apoptosis Is radiolabeled annexin V, an endogenous protein labeled with technectium-99m, now undergoing clinical trials in both Europe and the United States. While annexin V has been studied extensively in humans the precise mechanism(s) of uptake this agent in vivo is unclear and needs further study. Other agents are also under development, including radiolabeled forms of Z-VAD.fmk, a potent inhibitor of the enzymatic cascade intimately associated with apoptosis. In addition other technologies, such as diffusion weighted magnetic resonance imaging and magnetic resonance imaging with contrast agents, such as small paramagnetic iron oxide particles coated with peptides have also been advocated as methods to monitor apoptotic cell death. The potential applications of imaging apoptosis as a marker of early response to therapy in cancer, acute cerebral and myocardial ischemic injury and infarction, immune mediated inflammatory disease and transplant rejection are reviewed. |
| Keywords: | human cell; clinical trial; review; doxorubicin; dose response; drug efficacy; nonhuman; united states; nuclear magnetic resonance imaging; technetium 99m; radiopharmaceuticals; neoplasms; animal cell; animals; cell death; apoptosis; enzyme inhibition; brain injury; inflammation; cyclophosphamide; in vivo study; drug potency; enzyme inhibitor; caspase inhibitor; peptide; europe; nonhodgkin lymphoma; drug mechanism; isotope labeling; ischemia; heart infarction; breast carcinoma; scintiscanning; lung carcinoma; graft rejection; multienzyme complexes; diffusion weighted imaging; radionuclide imaging; heart muscle ischemia; synaptotagmin; lipocortin 5; inflammatory disease; organotechnetium compounds; superparamagnetic iron oxide; annexin a5; annexin v; phosphatidylserine; immune mediated injury; cancer; humans; human |
| Journal Title: | Quarterly Journal of Nuclear Medicine |
| Volume: | 47 |
| Issue: | 4 |
| ISSN: | 1125-0135 |
| Publisher: | Edizioni Minerva Medica |
| Date Published: | 2003-12-01 |
| Start Page: | 337 |
| End Page: | 348 |
| Language: | English |
| PUBMED: | 14973423 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
