EGF signaling patterns the feather array by promoting the interbud fate Journal Article
| Authors: | Atit, R.; Conlon, R. A.; Niswander, L. |
| Article Title: | EGF signaling patterns the feather array by promoting the interbud fate |
| Abstract: | Feather buds form sequentially in a hexagonal array. Bone morphogenetic protein (BMP) signaling from the feather bud inhibits bud formation in the adjacent interbud tissue, but whether interbud fate and patterning is actively promoted by BMP or other factors is unstimulate clear. We show that epidermal growth factor (EGF) signaling acts positively to establish interbud identity. EGF and the active EGF receptor (EGFR) are expressed in the interbud regions. Exogenous EGF stimulates epidermal proliferation and expands interbud gene expression, with a concurrent loss of feather bud gene expression and morphology. Conversely, EGFR inhibitors result in the loss of interbud fate and increased acquisition of feather bud fate. EGF signaling acts directly on the epidermis and is independent of BMP signaling. The timing of competence to interpret interbud-promoting signals occurs at an earlier developmental stage than previously anticipated. These data demonstrate that EGFR signaling actively promotes interbud identity. |
| Keywords: | immunohistochemistry; signal transduction; epidermal growth factor; controlled study; review; nonhuman; protein localization; cell proliferation; animals; animal tissue; cell division; gene expression; epidermis; bone morphogenetic protein; embryo; epidermal growth factor receptor; cell fate; embryo development; embryo pattern formation; receptor, epidermal growth factor; animalia; vertebrata; skin; in situ hybridization; gene expression regulation, developmental; immunoenzyme techniques; gefitinib; receptor blocking; body patterning; 2 morpholino 8 phenylchromone; gene structure; bromodeoxyuridine; chick embryo; chickens; bone morphogenetic proteins; 4 (3 chloroanilino) 6,7 dimethoxyquinazoline; priority journal; culture techniques; feather; feathers |
| Journal Title: | Developmental Cell |
| Volume: | 4 |
| Issue: | 2 |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Date Published: | 2003-02-01 |
| Start Page: | 231 |
| End Page: | 240 |
| Language: | English |
| DOI: | 10.1016/s1534-5807(03)00021-2 |
| PUBMED: | 12586066 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work