Seizures in children with systemic cancer Journal Article


Author: Antunes, N. L.
Article Title: Seizures in children with systemic cancer
Abstract: Children with cancer are a population with specific risk factors for the development of seizures. They present distinct problems in assessment and management that sets them apart from the usual pediatric patients. We reviewed the information gathered on our pediatric neurooncology database regarding 47 children with systemic cancer complicated by seizures. Leukemia was the most frequent underlying cancer (47%). In children with hematologic cancers, toxic-metabolic disturbances were the most frequent cause of seizures, whereas in patients with solid cancers, metastases were the single most common etiology. Children undergoing bone marrow transplant were particularly susceptible to seizures (34%), but only a minority progressed to develop a chronic seizure disorder (19.1%). Neuroimaging studies provided useful etiologic information in 62%. The choice of the antiseizure medication should take into account the potential interaction with the chemotherapy or supportive drugs often administered to these patients. © 2003 by Elsevier Inc. All rights reserved.
Keywords: adolescent; adult; cancer chemotherapy; child; clinical article; child, preschool; leukemia; busulfan; disease course; review; hypertension; solid tumor; brain radiation; prospective studies; neoplasms; metastasis; stem cell transplantation; diagnostic imaging; radiation injury; data base; risk factor; thiotepa; acute lymphoblastic leukemia; childhood cancer; chronic disease; hyponatremia; stroke; prophylaxis; brain metastasis; seizure; drug blood level; graft rejection; immunosuppressive treatment; tacrolimus; bone marrow transplantation; disease predisposition; databases, factual; metabolic disorder; cyclosporin; phenytoin; leukoencephalopathy; neurologic examination; gabapentin; neuroradiology; seizures; anticonvulsant therapy; central nervous system infection; neurologic complications; cavernous hemangioma; humans; human; male; female; priority journal
Journal Title: Pediatric Neurosurgery
Volume: 28
Issue: 3
ISSN: 1016-2291
Publisher: Karger  
Date Published: 2003-03-01
Start Page: 190
End Page: 193
Language: English
DOI: 10.1016/s0887-8994(02)00508-8
PUBMED: 12770671
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 25 September 2014 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Nuno L Antunes
    22 Antunes