Combined modality therapy in esophageal cancer: The Memorial experience Journal Article
| Authors: | Anderson, S. E.; Minsky, B. D.; Bains, M.; Kelsen, D. P.; Ilson, D. H. |
| Article Title: | Combined modality therapy in esophageal cancer: The Memorial experience |
| Abstract: | Over the past 20 years in the United States, esophageal cancer has shown the most rapid rate of increase of any solid tumor malignancy. Esophageal cancer is an aggressive disease, and poor survival is achieved with surgery or chemoradiation therapy alone. Ongoing trials are investigating the use of preoperative chemoradiation followed by surgical resection. Chemoradiation employing a combination of cisplatin and a continuous infusion of 5-fluorouracil (5-FU) is the most commonly used therapy. The significant gastrointestinal toxicity of traditional cisplatin/5-FU-based regimens has prompted the evaluation of new agents in combined-modality therapy. The Memorial Sloan-Kettering Cancer Center has conducted chemoradiation trials with weekly paclitaxel/cisplatin and irinotecan/cisplatin, and the results suggest that this regimen has the potential to improve the therapeutic index without compromising efficacy. Randomized trials are now being conducted to evaluate the tolerance and efficacy of paclitaxel/cisplatin in comparison with paclitaxel/5-FU combined with radiotherapy in locally advanced esophageal cancer. The incorporation of these non-5-FU-based therapies with novel biologic agents is planned. © 2003 Wiley-Liss, Inc. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; review; cisplatin; fluorouracil; diarrhea; dose response; drug efficacy; solid tumor; treatment planning; paclitaxel; cancer radiotherapy; combined modality therapy; neoadjuvant therapy; nephrotoxicity; blood toxicity; gastrointestinal symptom; nausea; stomatitis; antineoplastic combined chemotherapy protocols; camptothecin; irinotecan; asthenia; cancer invasion; neurologic disease; chemoradiation; esophagus carcinoma; esophageal neoplasms; esophageal cancer; multimodality therapy; humans; human; priority journal |
| Journal Title: | Seminars in Surgical Oncology |
| Volume: | 21 |
| Issue: | 4 |
| ISSN: | 8756-0437 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2003-11-01 |
| Start Page: | 228 |
| End Page: | 232 |
| Language: | English |
| DOI: | 10.1002/ssu.10041 |
| PUBMED: | 14648780 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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