BRCA1 and BRCA2 germline mutations in lymphoma patients Journal Article

  


Authors: Yossepowitch, O.; Olvera, N.; Satagopan, J. M.; Huang, H.; Jhanwar, S.; Rapaport, B.; Boyd, J.; Offit, K.
Article Title: BRCA1 and BRCA2 germline mutations in lymphoma patients
Abstract: Mutations in the BRCA1 and BRCA2 tumor suppressor genes are associated with an increased risk for breast and ovarian cancers as well as other types of malignancies. The observation of a germline BRCA1 mutation in an index case with a lymphoid neoplasm in the setting of a family history of breast cancer prompted us to explore the role of BRCA germline mutations as lymphoma susceptibility alleles. A panel of 286 DNA samples from Jewish lymphoma patients was analyzed for the three most frequent BRCA1 and BRCA2 germline mutations in those of Ashkenazi Jewish heritage, and compared to a cohort of 5010 DNA samples from healthy controls. Of the 286 cases, 2 patients carried a germline BRCA mutation; Both were diagnosed at an early age with an intermediate grade non-Hodgkin's lymphoma. This data indicate that germline BRCA mutations are not associated with an increased risk for lymphoid malignancies.
Keywords: adult; controlled study; aged; middle aged; leukemia; gene mutation; major clinical study; mutation; case-control studies; cancer risk; cancer patient; cancer grading; allele; cancer susceptibility; family health; ovary cancer; breast cancer; breast; cohort analysis; gene frequency; breast neoplasms; brca1 protein; brca2 protein; carcinogenesis; pedigree; germ line; tumor suppressor gene; dna; family history; lymphoma; age distribution; dna mutational analysis; jews; brca1; brca2; dna determination; germ-line mutation; jew; sampling; inheritance; lymphatic system tumor; humans; human; male; female; priority journal; article
Journal Title: Leukemia and Lymphoma
Volume: 44
Issue: 1
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2003-01-01
Start Page: 127
End Page: 131
Language: English
DOI: 10.1080/1042819021000040332
PUBMED: 12691152
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0037234810&partnerID=40&md5=2cabf27b65d4e7f782cd70369b31ca40
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Orit Yossepowitch
    3 Yossepowitch
  2. Kenneth Offit
    788 Offit
  3. Jaya M Satagopan
    141 Satagopan
  4. Jeffrey Boyd
    112 Boyd
  5. Sabrina M Jhanwar
    18 Jhanwar
  6. Narciso Olvera
    73 Olvera
  7. Helen Huang
    13 Huang
  8. Beth Rapaport
    5 Rapaport
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