Orthotopic urinary diversion after cystectomy for bladder cancer: Implications for cancer control and patterns of disease recurrence Journal Article
| Authors: | Yossepowitch, O.; Dalbagni, G.; Golijanin, D.; Donat, S. M.; Bochner, B. H.; Herr, H. W.; Fair, W. R.; Russo, P. |
| Article Title: | Orthotopic urinary diversion after cystectomy for bladder cancer: Implications for cancer control and patterns of disease recurrence |
| Abstract: | Purpose: The impact of orthotopic urinary diversion on the quality of cystectomy and ensuing cancer control has not been adequately studied. We analyzed our experience with this clinical problem. Materials and Methods: The records of 214 patients who underwent cystectomy and orthotopic diversion for bladder cancer were retrospectively evaluated and compared with those of 269 treated with an ileal conduit. Analyzed end points included overall and cancer specific survival. We specifically assessed the patterns of relapse and their association with pathological findings at cystectomy in the neobladder group. Results: No cancer specific survival difference was identified in the neobladder and ileal conduit cohorts when adjusting for pathological stage. Patterns of relapse in 62 of the 214 patients with a neobladder (29%) included local recurrence in 23 (11%), distant recurrence in 19 (9%), and combined local and distant recurrence in 18 (8%). Urethral recurrence was rare (2%). Of 10 patients (4.6%) diagnosed with upper tract recurrence 6 and 4 initially had relapse in the ureteroenteric anastomosis and renal pelvis, respectively. Five of the 6 patients with anastomotic relapse had evidence of disease in the intramural or juxtavesical ureter that was removed en bloc with the cystectomy specimen. Only 1 patient required neobladder takedown after such anastomotic recurrence. Conclusions: These results indicate that neobladders do not compromise the quality of preceding cystectomy or interfere with management in the presence of local or distant disease relapse. Our data suggest that involvement of the intramural or juxtavesical ureteral segment at cystectomy irrespective of surgical margin status may identify patients at higher risk for anastomotic recurrence, which is associated with an ominous prognosis. |
| Keywords: | adult; cancer survival; aged; middle aged; survival rate; retrospective studies; major clinical study; cancer recurrence; neoplasm recurrence, local; proportional hazards models; risk factors; relapse; bladder cancer; urinary bladder neoplasms; risk; carcinoma in situ; cystectomy; urinary diversion; neoplasm metastasis; bladder neoplasms; cancer control; ileum; hydronephrosis; ileal conduit; humans; human; male; female; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 169 |
| Issue: | 1 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-01-01 |
| Start Page: | 177 |
| End Page: | 181 |
| Language: | English |
| PUBMED: | 12478130 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0022-5347(05)64062-1 |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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