Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer Journal Article
| Authors: | Xing, H. R.; Cordon-Cardo, C.; Deng, X.; Tong, W.; Campodonico, L.; Fuks, Z.; Kolesnick, R. |
| Article Title: | Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer |
| Abstract: | Inhibition of the kinase suppressor of ras-1 (KSRI) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy. |
| Keywords: | drug activity; cancer growth; dose response; nonhuman; pancreas cancer; pancreatic neoplasms; cell proliferation; animals; mice; gene; gene targeting; protein kinases; protein targeting; lung non small cell cancer; antineoplastic activity; continuous infusion; tumor xenograft; drug effect; cell line, tumor; animalia; mus musculus; cancer inhibition; lung metastasis; mice, nude; transplantation, heterologous; gene inactivation; neoplasm transplantation; oncogene k ras; genes, ras; tumor growth; cell invasion; oncogene ras; oligonucleotides, antisense; metastasis inhibition; antisense oligonucleotide; humans; priority journal; article; oligodeoxynucleotide phosphorothioate; kinase suppressor of ras 1 gene |
| Journal Title: | Nature Medicine |
| Volume: | 9 |
| Issue: | 10 |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-10-01 |
| Start Page: | 1266 |
| End Page: | 1268 |
| Language: | English |
| PUBMED: | 12960962 |
| PROVIDER: | scopus |
| DOI: | 10.1038/nm927 |
| DOI/URL: | |
| Notes: | Erratum/Corrigendum issued, see DOI: 10.1038/nm1011-1320b -- Export Date: 12 September 2014 -- Source: Scopus |
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