Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer Journal Article


Authors: Xing, H. R.; Cordon-Cardo, C.; Deng, X.; Tong, W.; Campodonico, L.; Fuks, Z.; Kolesnick, R.
Article Title: Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer
Abstract: Inhibition of the kinase suppressor of ras-1 (KSRI) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.
Keywords: drug activity; cancer growth; dose response; nonhuman; pancreas cancer; pancreatic neoplasms; cell proliferation; animals; mice; gene; gene targeting; protein kinases; protein targeting; lung non small cell cancer; antineoplastic activity; continuous infusion; tumor xenograft; drug effect; cell line, tumor; animalia; mus musculus; cancer inhibition; lung metastasis; mice, nude; transplantation, heterologous; gene inactivation; neoplasm transplantation; oncogene k ras; genes, ras; tumor growth; cell invasion; oncogene ras; oligonucleotides, antisense; metastasis inhibition; antisense oligonucleotide; humans; priority journal; article; oligodeoxynucleotide phosphorothioate; kinase suppressor of ras 1 gene
Journal Title: Nature Medicine
Volume: 9
Issue: 10
ISSN: 1078-8956
Publisher: Nature Publishing Group  
Date Published: 2003-10-01
Start Page: 1266
End Page: 1268
Language: English
PUBMED: 12960962
PROVIDER: scopus
DOI: 10.1038/nm927
DOI/URL:
Notes: Erratum/Corrigendum issued, see DOI: 10.1038/nm1011-1320b -- Export Date: 12 September 2014 -- Source: Scopus
Altmetric Score
MSK Authors
  1. William Ping-Yiu Tong
    129 Tong
  2. Zvi Fuks
    309 Fuks
  3. Hongmei Xing
    12 Xing
  4. Richard N Kolesnick
    235 Kolesnick
  5. Xinzhu Deng
    10 Deng