MUC-1 mucin protein expression in B-cell lymphomas Journal Article

  


Authors: Teruya-Feldstein, J.; Donnelly, G. B.; Goy, A.; Hegde, A.; Nanjangud, G.; Qin, J.; Thaler, H.; Gilles, F.; Dyomin, V. G.; Lloyd, K. O.; Zelenetz, A. D.; Houldsworth, J.; Chaganti, R. S. K.
Article Title: MUC-1 mucin protein expression in B-cell lymphomas
Abstract: We have recently shown that MUC1, mapped to the chromosomal band 1q21, is rearranged or amplified in 15% of B-cell lymphomas and that rearrangement led to over-expression of MUC-1 mucin in a case of diffuse large B-cell lymphoma (DLBCL). To determine the incidence of MUC-1 mucin expression and its clinical significance in B-cell lymphomas, we investigated a panel of 113 cases by immunohistochemistry (IHC). MUC-1 mucin expression was detected in the majority of cases (92.9%), with moderate to high levels noted in 50.4% of all histologic subsets comprising DLBCL (82 cases), follicular lymphoma (FL) (15 cases), FL with transformation to DLBCL (4 cases), and other B-cell lymphomas (12 cases). No statistically significant correlation was found between MUC-1 mucin expression and MUC1 genomic status (amplification/rearrangement) evaluated by Southern blot analysis, and lq21 abnormality by karyotypic analysis. For all cases, MUC-1 mucin expression correlated with a previous history of lymphoma (p=0.003).
Keywords: immunohistochemistry; human tissue; protein expression; gene overexpression; cohort studies; gene amplification; incidence; gene mapping; b cell lymphoma; lymphoma, b-cell; gene rearrangement; large cell lymphoma; mucin 1; karyotype; chromosome 1q; mucin; southern blotting; ca-15-3 antigen; blotting, southern; chromosome band; humans; human; priority journal; article
Journal Title: Applied Immunohistochemistry & Molecular Morphology
Volume: 11
Issue: 1
ISSN: 1541-2016
Publisher: Lippincott Williams & Wilkins  
Date Published: 2003-03-01
Start Page: 28
End Page: 32
Language: English
DOI: 10.1097/00022744-200303000-00005
PUBMED: 12610353
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0037344959&partnerID=40&md5=6e41131981dac30a711625186c0698ad
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Vadim G Dyomin
    16 Dyomin
  2. Julie T Feldstein
    297 Feldstein
  3. Gerard Donnelly
    28 Donnelly
  4. Jing Qin
    86 Qin
  5. Frederic Gilles
    19 Gilles
  6. Abhijith Hegde
    10 Hegde
  7. Andrew D Zelenetz
    767 Zelenetz
  8. Raju S K Chaganti
    391 Chaganti
  9. Howard T Thaler
    245 Thaler
  10. Andre Goy
    30 Goy
  11. Jane Houldsworth El Naggar
    101 Houldsworth El Naggar
  12. Gouri J Nanjangud
    76 Nanjangud
  13. Kenneth O Lloyd
    163 Lloyd
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