Development of cellular multidrug resistance in response to exogenous stimuli Journal Article

  


Author: Shtil, A.
Article Title: Development of cellular multidrug resistance in response to exogenous stimuli
Abstract: Multidrug resistance (MDR) is a major cause of cancer progression. Tumor cells may acquire an MDR phenotype in response to many extracellular stimuli. MDR is commonly mediated by P-glycoprotein (Pgp), a transmembrane pump capable of transporting diverse compounds out of the cell. The increased amount of Pgp is associated with elevated level of mRNA of the MDR1 gene that encodes Pgp in humans. Intracellular signals triggered by xenobiotics (including anticancer drugs) converge to MDR1 overexpression, thereby leading to establishment of Pgp-mediated MDR in tumor cells. Signal transduction pathways and the MDR1 gene transcription are considered as targets for therapeutic intervention to block the emergence of MDR during treatment.
Keywords: signal transduction; cancer growth; antineoplastic agent; protein function; phenotype; gene targeting; gene overexpression; genetic transcription; messenger rna; tumor cell; cell stimulation; genetic code; multidrug resistance; cell membrane transport; glycoprotein p; xenobiotic agent; article
Journal Title: Biologicheskie Membrany
Volume: 20
Issue: 3
ISSN: 0233-4755
Publisher: Mezhdunarodnaya Kniga  
Date Published: 2003-01-01
Start Page: 236
End Page: 243
Language: Russian
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0038391509&partnerID=40&md5=e319cc9a4a9a0a233140687705f17687
Notes: Export Date: 12 September 2014 -- Source: Scopus