Tumor suppressor role of KiSS-1 in bladder cancer: Loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome Journal Article

   

Authors:	Sanchez Carbayo, M.; Capodieci, P.; Cordon-Cardo, C.
Article Title:	Tumor suppressor role of KiSS-1 in bladder cancer: Loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome
Abstract:	The expression profiles of nine bladder cancer cell lines were compared against a pool containing equal total RNA quantities of each of them. Lower expression of KiSS-1 was revealed in cells derived from the most advanced bladder tumors. When comparing 15 primary bladder tumors versus a pool of four bladder cancer cell lines, lower transcript levels of KiSS-1 were observed in the invasive bladder carcinomas as compared to superficial tumors. KiSS-1 expression ratios provided prognostic information. The expression pattern of KiSS-1 transcripts was analyzed using in situ hybridization in nine bladder cancer cells, paired normal urothelium and bladder tumor samples (n = 25), and tissue microarrays of bladder tumors (n = 173). We observed complete loss of KiSS-1 in all invasive tumors under study as compared to their respective normal urothelium. The expression of KiSS-1 was found to be significantly associated with histopathological stage. Patients with lower KiSS-1 expression showed a direct correlation with overall survival in a subset of bladder tumors whose follow-up was available (n = 69). We did not observe any significant differential KiSS-1 expression along cell cycle by sorting analysis. A potential tumor suppressor role in bladder cancer was revealed for KiSS-1. Moreover, it showed predictive value by identifying patients with poor outcome.
Keywords:	adult; cancer survival; controlled study; human tissue; treatment outcome; aged; aged, 80 and over; middle aged; survival analysis; unclassified drug; human cell; advanced cancer; cancer growth; neoplasm staging; proteins; cell cycle; gene expression; smoking; cancer cell culture; tumor cells, cultured; bladder cancer; urinary bladder neoplasms; time factors; cancer invasion; in situ hybridization; urothelium; oligonucleotide array sequence analysis; disease progression; nucleotide sequence; carcinoma in situ; tumor suppressor proteins; gene loss; outcomes research; bladder carcinoma; tumor suppressor protein; genes, tumor suppressor; genes, p53; genes, retinoblastoma; humans; human; male; female; priority journal; article; protein kiss 1
Journal Title:	American Journal of Pathology
Volume:	162
Issue:	2
ISSN:	0002-9440
Publisher:	Elsevier Science, Inc.
Date Published:	2003-02-01
Start Page:	609
End Page:	617
Language:	English
PUBMED:	12547718
PROVIDER:	scopus
PMCID:	PMC1851149
DOI:	10.1016/S0002-9440(10)63854-0
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0037331838&partnerID=40&md5=912db7eeb4de038194873d71293f0295
Notes:	Export Date: 12 September 2014 -- Source: Scopus

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