Listeriosis in patients at a comprehensive cancer center, 1955-1997 Journal Article
| Authors: | Safdar, A.; Armstrong, D. |
| Article Title: | Listeriosis in patients at a comprehensive cancer center, 1955-1997 |
| Abstract: | Listeria monocytogenes infection occurred in 94 patients during 1955-1997 at Memorial Sloan-Kettering Cancer Center. The incidence was 0.5 (1955-1966), 0.96 (1970-1979), and 0.14 (1985-1997) cases per 1000 new admissions. Eighty-five patients (90%) were bacteremic, and 34 (36%) had evidence of intracranial infection. In 91 patients with cancer, 70 (77%) received chemotherapy for advanced or relapsed malignancy (n = 51; 56%); 64 (68%) received corticosteroids. Breast cancer was the most common solid-organ cancer (n = 14; 45%), and 34 (36%) had preexisting advanced liver disease. In 14 (39%) of 37 patients who died of listeriosis, death occurred within 48 h of L. monocytogenes isolation. Four (80%) of 5 patients with extracranial foci of infection died of their infection, compared with 33 (37%) of 89 patients with isolated bacteremia and/or intracranial infection (odds ratio, 2.34; P = .05). Most infections (60%) were due to L. monocytogenes serotype 1/2, and the remainder (40%) were due to serovar 4b. Listeriosis in these patients with cancer occurred most often in individuals receiving antineoplastic therapy for advanced or relapsed malignancy and systemic corticosteroids. The presence of advanced liver disease may have increased the risk of systemic listeriosis in susceptible patients with underlying cancer. |
| Keywords: | adolescent; adult; cancer chemotherapy; child; controlled study; treatment outcome; aged; aged, 80 and over; child, preschool; middle aged; retrospective studies; major clinical study; cancer recurrence; nonhuman; united states; neoplasms; incidence; risk assessment; cause of death; cancer center; anti-bacterial agents; disease severity; drug therapy, combination; breast carcinoma; liver disease; pregnancy; hospital admission; bacteremia; corticosteroid; listeriosis; listeria monocytogenes; listeria infections; bacterium isolation; corticosteroid therapy; brain infection; serotype; serotyping; humans; human; male; female; priority journal; article |
| Journal Title: | Clinical Infectious Diseases |
| Volume: | 37 |
| Issue: | 3 |
| ISSN: | 1058-4838 |
| Publisher: | Oxford University Press |
| Date Published: | 2003-08-01 |
| Start Page: | 359 |
| End Page: | 364 |
| Language: | English |
| DOI: | 10.1086/376631 |
| PUBMED: | 12884160 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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