Long-term follow-up of bilateral sporadic renal tumors Journal Article


Authors: Patel, M. I.; Simmons, R.; Kattan, M. W.; Motzer, R. J.; Reuter, V. E.; Russo, P.
Article Title: Long-term follow-up of bilateral sporadic renal tumors
Abstract: Objectives. To assess the clinical characteristics, pathology, and long-term follow-up of patients with bilateral nonfamilial renal tumors (BNFRTs). Methods. Patients with BNFRTs and unilateral tumors were identified from a prospective surgery database. The Mann-Whitney U test, Cox proportional hazards regression analysis, and the log-rank test were used to compare groups. Results. From a database of 1082 patients with nonmetastatic renal tumors, 46 were identified with BNFRTs (4.25%). Thirty-three had synchronous tumors and 13 had asynchronous tumors. The median patient age of BNFRT patients was 61 years. Of the 92 renal tumors in these 46 patients, 42% were managed with radical nephrectomy (RN) and 58% with partial nephrectomy (PN); 7 underwent bilateral PN. The tumors were conventional clear cell carcinoma in 66% (n = 61), papillary carcinoma in 14% (n = 13), and the remaining 20% were of varied histologic origin. A 76.2% concordance was noted between the histologic subtypes of the two renal tumors in each patient. Median follow-up was 74 months. Thirty-three patients (72%) were disease-free and 7 patients had recurrence (2 local, 5 metastatic). Compared with patients having unilateral disease, BNFRT patients had an equivalent disease-free survival (DFS) (bilateral: 3-year DFS 90%, 5-year DFS 83%; unilateral: 3-year DFS 92%, 5-year DFS 82% [P = 0.449]). No difference in DFS was observed between synchronous and asynchronous tumors. Conclusions. BNFRTs were present in 4.25% of patients with sporadic renal tumors. Conventional clear cell histology was the most common histologic subtype; concordance among tumors was found to be 76%. DFS rates comparable to those of unilateral tumors can be obtained by using combinations of PN and RN. © 2003, Elsevier Inc.
Keywords: cancer survival; clinical article; controlled study; disease-free survival; middle aged; clinical feature; histopathology; cancer recurrence; follow up; brain neoplasms; follow-up studies; cancer diagnosis; prospective study; prospective studies; neoplasm recurrence, local; lung neoplasms; data base; information processing; kidney carcinoma; kidney neoplasms; nephrectomy; kidney tumor; long term care; clear cell carcinoma; papillary carcinoma; regression analysis; databases, factual; neoplasms, multiple primary; rank sum test; humans; human; priority journal; article
Journal Title: Urology
Volume: 61
Issue: 5
ISSN: 0090-4295
Publisher: Elsevier Science, Inc.  
Date Published: 2003-05-01
Start Page: 921
End Page: 925
Language: English
DOI: 10.1016/s0090-4295(02)02578-5
PUBMED: 12736005
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Manish Patel
    11 Patel
  2. Paul Russo
    457 Russo
  3. Robert Motzer
    769 Motzer
  4. Victor Reuter
    922 Reuter
  5. Michael W Kattan
    218 Kattan