Prospective identification of risk factors for wound infection after lower extremity oncologic surgery Journal Article
| Authors: | Morris, C. D.; Sepkowitz, K.; Fonshell, C.; Margetson, N.; Eagan, J.; Miransky, J.; Boland, P. J.; Healey, J. |
| Article Title: | Prospective identification of risk factors for wound infection after lower extremity oncologic surgery |
| Abstract: | Background: Surgical site infections (SSI) are frequent causes of morbidity and mortality after orthopaedic oncologic procedures. This study was conducted to identify the surgical site infection rate following a lower extremity or pelvic procedure and assess the risk factors for acquiring SSI by direct observation of orthopaedic oncology patients' wounds at a comprehensive cancer center. Methods: One hundred ten consecutive patients were prospectively studied. The surveillance of surgical site infections was carried out by a surgeon-trained nurse from the Infectious Disease Service. Nineteen variables were analyzed as risk factors. Results: The overall SSI rate was 13.6% (15 of 110). Excluding those patients with known preoperative infections, the SSI rate was 9.5% (10 of 105). Two statistically significant risk factors for surgical site infection in these patients emerged in the multivariate analysis: blood transfusion (P = .007) and obesity (P = .016). Procedure category was significant in univariate analysis only. Preoperative length of stay, length of procedure, prior adjuvant treatment (chemotherapy or radiotherapy), prior surgery, and use of an implant or allograft were not statistically significant risk factors for wound infection. Antibiotic usage patterns did not influence SSI rate. Conclusions: Blood transfusion and obesity should be considered individual risk factors for the development of wound infection in patients having orthopaedic oncologic procedures. © 2003 The Society of Surgical Oncology, Inc. |
| Keywords: | cancer chemotherapy; controlled study; bone neoplasms; bone tumor; cancer surgery; major clinical study; mortality; cancer radiotherapy; prospective study; prospective studies; morbidity; risk factors; obesity; risk factor; hospitalization; statistical analysis; preoperative period; surgical infection; blood transfusion; complications; wound infection; postmarketing surveillance; soft tissue neoplasms; soft tissue tumor; orthopedic surgery; surgical wound infection; surgical site infection; humans; human; male; female; article; orthopaedic oncology |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 10 |
| Issue: | 7 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2003-08-01 |
| Start Page: | 778 |
| End Page: | 782 |
| Language: | English |
| DOI: | 10.1245/aso.2003.07.023 |
| PUBMED: | 12900369 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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