Microvascular function regulates intestinal crypt response to radiation Journal Article
| Authors: | Maj, J. G.; Paris, F.; Haimovitz-Friedman, A.; Venkatraman, E.; Kolesnick, R.; Fuks, Z. |
| Article Title: | Microvascular function regulates intestinal crypt response to radiation |
| Abstract: | Recent evidence suggests that microvascular endothelial apoptosis represents the primary lesion in radiation damage to the gastrointestinal (GI) tract. Rescue of endothelium by depletion of acid sphingomyelinase or i.v. treatment with basic fibroblast growth factor (FGF) prevented the lethal GI syndrome in C57Bl/6 mice. Here we show that basic FGF increased crypt survival after irradiation by 2-3 fold, with a dose modification factor at D10 of 1.15 (P < 0.01). Basic FGF inhibited initial crypt damage, assessed by crypt shrinkage at 18-24 h, but did not significantly affect the regeneration of surviving crypts at 3.5 days after irradiation. These data suggest that microvascular function regulates expression of radiation-induced crypt stem cell clonogen damage in the evolution of radiation injury to the GI mucosa. |
| Keywords: | controlled study; nonhuman; radiation dose; animal cell; mouse; animals; mice; animal tissue; cell survival; apoptosis; animal experiment; radiation injury; mice, inbred c57bl; regeneration; fibroblast growth factor 2; endothelium, vascular; irradiation; microvasculature; gastrointestinal disease; jejunum; intestine crypt; sphingomyelin phosphodiesterase; intestinal mucosa; basic fibroblast growth factor; male; priority journal; article |
| Journal Title: | Cancer Research |
| Volume: | 63 |
| Issue: | 15 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2003-08-01 |
| Start Page: | 4338 |
| End Page: | 4341 |
| Language: | English |
| PUBMED: | 12907601 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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